{"id":"W2148849324","doi":"10.1177/1087057110387425","title":"Fusogenics: A Recombinant Immunotoxin-Based Screening Platform to Select Internalizing Tumor-Specific Antibody Fragments","year":2010,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Immunotoxin; Recombinant DNA; Antibody; Cancer research; Medicine; Chemistry; Monoclonal antibody; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005132047,0.0004826977,0.0005369821,0.0003371359,0.0004759609,0.0002275853,0.0008016004,0.0003086314,0.00123158],"category_scores_gemma":[0.00009260379,0.0004390588,0.0003310875,0.0003383785,0.0001313932,0.0005474347,0.0003000601,0.001123239,0.001299865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008531992,"about_ca_system_score_gemma":0.0001379834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002339701,"about_ca_topic_score_gemma":0.0000911157,"domain_scores_codex":[0.9974334,0.00009079032,0.0006441947,0.0007227517,0.0001285643,0.0009803429],"domain_scores_gemma":[0.9986239,0.0001340917,0.0002411548,0.0008431199,0.00008231784,0.00007540976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004841744,0.0002382534,0.001639603,0.00001447188,0.0001829391,0.0000292522,0.000228226,0.00001523912,0.9879105,0.003517585,0.000934826,0.004804903],"study_design_scores_gemma":[0.002824608,0.0005661472,0.006962377,0.0002572436,0.00004412375,0.0001189517,0.0003675035,0.00004910615,0.8992345,0.0005290966,0.08824944,0.000796911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721667,0.0009059353,0.0195896,0.0001060582,0.005606426,0.0006275112,0.00008432412,0.0001779334,0.0007355551],"genre_scores_gemma":[0.9946572,0.00004285475,0.001997565,0.0006407106,0.0001010986,0.00007455732,0.0002409193,0.00008838576,0.002156725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08867603,"threshold_uncertainty_score":0.9998061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318991412032419,"score_gpt":0.2566943702054862,"score_spread":0.2435044560851621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}