{"id":"W2148849694","doi":"10.1093/jn/134.4.711","title":"Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo: A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize","year":2004,"lang":"en","type":"review","venue":"Journal of Nutrition","topic":"Mycotoxins in Agriculture and Food","field":"Agricultural and Biological Sciences","cited_by":601,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"National Institute of General Medical Sciences; Centers for Disease Control and Prevention","keywords":"Neural tube; Fumonisin; Sphingolipid; Biology; Fumonisin B1; Ceramide synthase; Neural tube defect; Embryo; Biochemistry; Cell biology; Genetics; Fusarium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004215795,0.0008736111,0.001079472,0.001177331,0.0001712362,0.0005523991,0.0006115714,0.0009066932,0.001609283],"category_scores_gemma":[0.000414404,0.0002264512,0.0002528426,0.001387781,0.0002297808,0.0006321417,0.0002743955,0.0005758794,0.001403245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004109134,"about_ca_system_score_gemma":0.0006950446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002899232,"about_ca_topic_score_gemma":0.006544648,"domain_scores_codex":[0.9998913,0.00001222895,0.00001599373,0.00001924779,0.00005122406,0.00001004489],"domain_scores_gemma":[0.9997584,0.00008660054,0.0000376669,0.000007371217,0.00009025897,0.00001968153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001316273,0.00006437068,0.0005107434,0.005920663,0.00008942475,0.0002727476,0.00003331005,0.0002753814,0.00791722,0.0006927665,0.0108153,0.9732764],"study_design_scores_gemma":[0.00004597964,0.0002877279,0.004465504,0.001760314,0.0003067995,0.002860822,0.0001125176,0.0001578436,0.006985836,0.0009024226,0.9820888,0.00002528226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004238831,0.9982786,0.0002159632,0.0001442021,0.0001029203,0.000003673324,0.00001999131,0.000008057892,0.0008027599],"genre_scores_gemma":[0.00141895,0.997053,0.000279668,0.00006393272,0.00005082404,0.000003586962,0.00003070203,7.939832e-7,0.001098504],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002899232,"threshold_uncertainty_score":0.005764723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02934120517703098,"score_gpt":0.2734153930479188,"score_spread":0.2440741878708879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}