{"id":"W2148856565","doi":"10.1038/ncb2293","title":"FOXO1 is an essential regulator of pluripotency in human embryonic stem cells","year":2011,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":267,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Howard Hughes Medical Institute","keywords":"SOX2; FOXO1; Homeobox protein NANOG; Reprogramming; Embryonic stem cell; Biology; Stem cell; Cell biology; Regulator; Induced pluripotent stem cell; Transcription factor; LIN28; Somatic cell; Rex1; Nanog Homeobox Protein; Protein kinase B; Genetics; Signal transduction; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002141528,0.0002861513,0.0002452132,0.0002473876,0.0003905307,0.0004509808,0.0001943375,0.0002081626,0.001664115],"category_scores_gemma":[0.0002229854,0.0002131372,0.0002836015,0.000202827,0.0002915295,0.0002828845,0.0004689236,0.0004194255,0.00053062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000545366,"about_ca_system_score_gemma":0.0003850229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005441531,"about_ca_topic_score_gemma":0.00120757,"domain_scores_codex":[0.9998944,0.000009057716,0.00000993203,0.00003411898,0.00002940693,0.00002305132],"domain_scores_gemma":[0.9998655,0.00001548142,0.00004095143,0.0000140083,0.00001602107,0.00004797356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003749626,0.000019667,0.001686811,0.0001257458,0.0000136881,0.0001416546,0.00002487888,0.0001765766,0.9891951,0.0008138172,0.0005586026,0.006868437],"study_design_scores_gemma":[0.0001070644,0.0003502989,0.03820926,0.00004054455,0.0000723956,0.001047532,0.0001081682,0.001705453,0.9283821,0.001244759,0.02870884,0.00002365411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685107,0.0131513,0.008268742,0.001033656,0.0003873464,0.00004712546,0.001921134,0.0003850087,0.006294953],"genre_scores_gemma":[0.9854528,0.002555053,0.002547296,0.0002035093,0.00005499153,0.00002354262,0.002024273,0.00007807982,0.007060439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001664115,"threshold_uncertainty_score":0.005566955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394285910172173,"score_gpt":0.2703807540505226,"score_spread":0.2564378949488009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}