{"id":"W2148856565","doi":"10.1038/ncb2293","title":"FOXO1 is an essential regulator of pluripotency in human embryonic stem cells","year":2011,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":267,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Howard Hughes Medical Institute","keywords":"SOX2; FOXO1; Homeobox protein NANOG; Reprogramming; Embryonic stem cell; Biology; Stem cell; Cell biology; Regulator; Induced pluripotent stem cell; Transcription factor; LIN28; Somatic cell; Rex1; Nanog Homeobox Protein; Protein kinase B; Genetics; Signal transduction; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000336724,0.0002464479,0.0003240105,0.0001850501,0.00005567666,0.000006598417,0.0006701602,0.001216759,0.0001844129],"category_scores_gemma":[0.000008846009,0.0002274989,0.0001397193,0.0001910716,0.0002281204,0.000006946682,0.0002581899,0.0005198247,0.00002044303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002332347,"about_ca_system_score_gemma":0.0001126174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008114183,"about_ca_topic_score_gemma":0.00009972059,"domain_scores_codex":[0.9979888,0.0002448552,0.0003715083,0.0007174518,0.0001494014,0.0005280292],"domain_scores_gemma":[0.9987916,0.00001185481,0.0001687066,0.0007542038,0.0001399035,0.0001337503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001455568,0.0002542402,0.002380257,0.00006613204,0.0000288442,0.00001109491,0.0001316912,0.000002750226,0.9956001,0.0002152394,0.0006034089,0.0005607046],"study_design_scores_gemma":[0.0007905844,0.000719872,0.001641669,0.00001064286,0.00001220899,0.000004917152,0.00006047697,0.0000233789,0.9889145,0.0002253758,0.007359365,0.0002369731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913323,0.002644744,0.00004874336,0.00003284681,0.0003127739,0.00030258,0.00005066091,0.0000131823,0.005262193],"genre_scores_gemma":[0.9969881,0.0002509242,0.0003167639,0.000131852,0.0001534805,0.00001434489,0.0001212519,0.00003440712,0.001988841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006755956,"threshold_uncertainty_score":0.938476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394285910172173,"score_gpt":0.2703807540505226,"score_spread":0.2564378949488009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}