{"id":"W2148869006","doi":"10.1007/s00125-010-1671-6","title":"Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?","year":2010,"lang":"en","type":"review","venue":"Diabetologia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of British Columbia; Child and Family Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Islet; Cytotoxicity; Amyloid (mycology); Fibril; Programmed cell death; Cytotoxic T cell; Chemistry; Beta cell; Amylin; Peptide; Cell biology; Amyloid disease; Oligomer; Cell; In vitro; Biochemistry; Biology; Diabetes mellitus; Disease; Apoptosis; Amyloid fibril; Internal medicine; Endocrinology; Medicine; Amyloid β","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001266119,0.00118351,0.003988742,0.002222678,0.0004252682,0.00177349,0.001665073,0.0030891,0.003746479],"category_scores_gemma":[0.002281589,0.000470646,0.0008248499,0.003296976,0.00132353,0.002537068,0.000954202,0.002289328,0.001385109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008074532,"about_ca_system_score_gemma":0.001756719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002294923,"about_ca_topic_score_gemma":0.005194604,"domain_scores_codex":[0.9996015,0.0001033491,0.00006899647,0.00005564043,0.0001355641,0.00003487047],"domain_scores_gemma":[0.9989505,0.0006008075,0.0002534376,0.00002730598,0.000126801,0.0000411321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003146096,0.00009070976,0.0006456762,0.04807925,0.0007765475,0.001268884,0.0001812277,0.0001877941,0.000583178,0.005094751,0.05630969,0.8864678],"study_design_scores_gemma":[0.0002247796,0.0001608256,0.003473039,0.04445937,0.001586095,0.009139032,0.0008255467,0.0001625053,0.0004218453,0.01159861,0.9278687,0.00007954219],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005070095,0.9994457,0.00001992378,0.0002168407,0.00007481362,0.000001380283,0.000004556163,9.816879e-7,0.0001850693],"genre_scores_gemma":[0.0005485209,0.9989209,0.00004336952,0.000219581,0.0001275758,0.000002062179,0.000008851327,3.441179e-7,0.0001287735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003988742,"threshold_uncertainty_score":0.01253325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06688142351126827,"score_gpt":0.3672369116324502,"score_spread":0.300355488121182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}