{"id":"W2148873733","doi":"10.1002/bit.21449","title":"Activity of human P450 2D6 in biphasic solvent systems","year":2007,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cofactor; Substrate (aquarium); Chemistry; Solvent; Hydrogen peroxide; Redox; Combinatorial chemistry; Enzyme; Organic synthesis; Organic chemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000406503,0.0003406764,0.000269601,0.0002258554,0.00013353,0.0002479396,0.0001639907,0.0002485278,0.0009028999],"category_scores_gemma":[0.0005264422,0.0001051519,0.0001731501,0.000349632,0.00015775,0.000206995,0.0002302199,0.0004009076,0.0004912372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002340191,"about_ca_system_score_gemma":0.0001945086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008499103,"about_ca_topic_score_gemma":0.0008622404,"domain_scores_codex":[0.9995992,0.0001418369,0.00003226196,0.00008966091,0.00009928118,0.00003783888],"domain_scores_gemma":[0.9998389,0.00005677454,0.00002678131,0.00001907658,0.00003920031,0.00001909121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002674863,0.00004649301,0.0001981817,0.00008319762,0.000008212445,0.00004445877,0.00003353736,0.0001661513,0.9954842,0.00008573347,0.00007212792,0.003510293],"study_design_scores_gemma":[0.00002001127,0.000299934,0.000432022,0.000003591312,0.000008097369,0.0001134591,0.000009946673,0.0006155964,0.9968295,0.00003096526,0.001632875,0.000004118127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659505,0.005911889,0.02421087,0.000211142,0.00006879545,0.0001158518,0.0008783289,0.0001641358,0.002488493],"genre_scores_gemma":[0.9776199,0.002837619,0.01258693,0.00006242473,0.00003983792,0.00008494419,0.001961599,0.0000422831,0.004764388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009028999,"threshold_uncertainty_score":0.003020465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06988047184778479,"score_gpt":0.3927873405314329,"score_spread":0.3229068686836482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}