{"id":"W2148873733","doi":"10.1002/bit.21449","title":"Activity of human P450 2D6 in biphasic solvent systems","year":2007,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cofactor; Substrate (aquarium); Chemistry; Solvent; Hydrogen peroxide; Redox; Combinatorial chemistry; Enzyme; Organic synthesis; Organic chemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008493178,0.0001853105,0.0003117586,0.0004599392,0.00007511728,0.000005253547,0.0001814216,0.0006485904,0.00002090115],"category_scores_gemma":[0.00001909887,0.0001830341,0.00004602731,0.0003392169,0.0002145124,0.00004288111,0.0001073751,0.0006448378,0.000004238635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003029536,"about_ca_system_score_gemma":0.00001474628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004293175,"about_ca_topic_score_gemma":0.00001952836,"domain_scores_codex":[0.998868,0.0000442393,0.0003282051,0.0002499278,0.00007476553,0.000434816],"domain_scores_gemma":[0.9995397,0.00008179754,0.00009651497,0.0001560548,0.00002325191,0.0001026752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005313331,0.0001021181,0.006644246,0.00008710621,0.00006645809,0.0000367044,0.00007589544,0.000289398,0.971153,0.005884273,0.00001572145,0.0155919],"study_design_scores_gemma":[0.001120655,0.00009489245,0.01915539,0.00002651505,0.00005386975,0.0000325395,0.00006137555,0.003585354,0.9639224,0.00008069938,0.01164054,0.0002257164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918776,0.005354041,0.001179668,0.0002071128,0.0006728033,0.0002309804,0.00001520643,0.0001103324,0.0003523135],"genre_scores_gemma":[0.9988751,0.0008163867,0.0001097878,0.00004005148,0.00008624948,0.0000105997,0.000002587791,0.00001541921,0.00004377622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01536619,"threshold_uncertainty_score":0.7463916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06988047184778479,"score_gpt":0.3927873405314329,"score_spread":0.3229068686836482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}