{"id":"W2148894885","doi":"10.1038/cr.2009.129","title":"S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3","year":2009,"lang":"en","type":"article","venue":"Cell Research","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba; CancerCare Manitoba","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; CancerCare Manitoba Foundation; National Institutes of Health; Deutsche Forschungsgemeinschaft; Deutsche Krebshilfe; Manitoba Health Research Council","keywords":"Programmed cell death; Autophagy; Cell biology; Biology; ATG5; Mitochondrion; Apoptosis; Reactive oxygen species; Bafilomycin; Vacuole; Cytoplasm; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002457059,0.0005020904,0.0003499078,0.0005169799,0.0003175548,0.0003837214,0.0003044475,0.0006014231,0.001927103],"category_scores_gemma":[0.0001502118,0.0002938143,0.0006483056,0.0002528722,0.0003600586,0.0004353277,0.0004080563,0.001188175,0.0007176659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007483153,"about_ca_system_score_gemma":0.0002690337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000721026,"about_ca_topic_score_gemma":0.001226321,"domain_scores_codex":[0.9997548,0.00003875957,0.00002466134,0.00003985998,0.00007006154,0.00007178145],"domain_scores_gemma":[0.9998804,0.00001613603,0.0000312753,0.00002164774,0.00001932251,0.00003122874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006959684,0.0001042127,0.0002249309,0.00004021041,0.00001978064,0.0001248589,0.000006974228,0.00005129799,0.9964702,0.0001124643,0.0001456744,0.002003283],"study_design_scores_gemma":[0.0001005581,0.0003259334,0.007845513,0.000008288495,0.00002190891,0.0005934671,0.0000342993,0.001322271,0.9874656,0.0001779373,0.002097798,0.000006434227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919074,0.001699668,0.002563266,0.0005246218,0.0001149373,0.00005370354,0.0004991527,0.0001643842,0.002472971],"genre_scores_gemma":[0.9933629,0.0007467463,0.00189664,0.0001081239,0.00001843492,0.00005590367,0.0006635824,0.00003031247,0.003117413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001927103,"threshold_uncertainty_score":0.006446838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07420105121293813,"score_gpt":0.38634062116394,"score_spread":0.3121395699510018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}