{"id":"W2148894885","doi":"10.1038/cr.2009.129","title":"S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3","year":2009,"lang":"en","type":"article","venue":"Cell Research","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba; CancerCare Manitoba","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; CancerCare Manitoba Foundation; National Institutes of Health; Deutsche Forschungsgemeinschaft; Deutsche Krebshilfe; Manitoba Health Research Council","keywords":"Programmed cell death; Autophagy; Cell biology; Biology; ATG5; Mitochondrion; Apoptosis; Reactive oxygen species; Bafilomycin; Vacuole; Cytoplasm; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006194033,0.0002722249,0.0004809612,0.0004130632,0.0003695759,0.0002113614,0.0002312444,0.0003084395,0.0003220368],"category_scores_gemma":[0.0001521263,0.0002256267,0.00008623056,0.0004983436,0.000607673,0.0002629298,0.0001329656,0.000678328,0.00007616017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006526881,"about_ca_system_score_gemma":0.0001750963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008383581,"about_ca_topic_score_gemma":0.000002249476,"domain_scores_codex":[0.9972557,0.0001871993,0.0002991584,0.0006221067,0.0008691594,0.0007666571],"domain_scores_gemma":[0.9980199,0.0005394059,0.00006869975,0.0004864057,0.0002078276,0.0006777537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007251919,0.0006709225,0.1355289,0.0004600782,0.0002808822,0.0002356282,0.002215194,6.702814e-7,0.7814558,0.0001156374,0.003801615,0.0745095],"study_design_scores_gemma":[0.002464694,0.0007221551,0.4745158,0.00009004041,0.00004884927,0.000009982897,0.0002523592,0.00005684063,0.5172311,0.001758641,0.002619876,0.00022961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848249,0.01027315,0.00001321742,0.0008667447,0.0000825452,0.000632408,0.00002347051,0.0001059758,0.003177571],"genre_scores_gemma":[0.9935417,0.00246583,0.0001576051,0.0003264147,0.00038621,0.00003293761,0.0000906848,0.0000392447,0.002959371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3389869,"threshold_uncertainty_score":0.920079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07420105121293813,"score_gpt":0.38634062116394,"score_spread":0.3121395699510018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}