{"id":"W2148947217","doi":"10.1093/jnci/djj091","title":"Randomized Phase III Trial of Low-dose Isotretinoin for Prevention of Second Primary Tumors in Stage I and II Head and Neck Cancer Patients","year":2006,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hamilton Regional Laboratory Medicine Program; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Isotretinoin; Medicine; Hazard ratio; Internal medicine; Placebo; Cancer; Oncology; Confidence interval; Gastroenterology; Surgery; Acne; Pathology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002014184,0.001370443,0.002757573,0.0003228776,0.0005280172,0.001015701,0.0009685017,0.001766926,0.007359148],"category_scores_gemma":[0.002146114,0.0005599497,0.001724575,0.0003783916,0.001152571,0.0007504956,0.0004190191,0.003031389,0.001001266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001083126,"about_ca_system_score_gemma":0.001972775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328334,"about_ca_topic_score_gemma":0.003055532,"domain_scores_codex":[0.9992556,0.000446206,0.00003928104,0.0001163782,0.00004286969,0.00009955932],"domain_scores_gemma":[0.9982975,0.0004640394,0.0003537662,0.000149733,0.0001405394,0.0005944296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9844047,0.005238065,0.0005806921,0.0002155317,0.0004309169,0.00002787912,0.00002567943,0.0001671623,0.001598262,0.0000518313,0.0006843537,0.006574885],"study_design_scores_gemma":[0.9532507,0.04484328,0.0009843009,0.00001197387,0.0001663506,0.00001967521,0.000009858721,0.0001681983,0.0001545854,0.00007116092,0.0003145455,0.000005332968],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808276,0.004225287,0.0008236925,0.001087937,0.00101364,0.008037148,0.001589469,0.0001237694,0.002271449],"genre_scores_gemma":[0.9786482,0.001889596,0.002023138,0.002278661,0.0005053913,0.009123047,0.002082944,0.00002942394,0.003419671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007359148,"threshold_uncertainty_score":0.0246188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03537186895344963,"score_gpt":0.3602572965503432,"score_spread":0.3248854275968935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}