{"id":"W2148994398","doi":"10.4049/jimmunol.0902474","title":"Transient Receptor Potential Melastatin 2 Is Required for Lipopolysaccharide-Induced Cytokine Production in Human Monocytes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fraunhofer-Institut für Zelltherapie und Immunologie; Universität Regensburg; Universitetet i Bergen; Deutsche Forschungsgemeinschaft; York University; F. Hoffmann-La Roche; NYU Langone Medical Center","keywords":"TRPM2; Downregulation and upregulation; Monocyte; Transient receptor potential channel; Lipopolysaccharide; Cell biology; Cytokine; Chemistry; Intracellular; Tumor necrosis factor alpha; Receptor; Biology; Biochemistry; Immunology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002186659,0.0002380752,0.000480559,0.0001612823,0.000238561,0.0006040233,0.0001157032,0.000294074,0.001550504],"category_scores_gemma":[0.0005402085,0.0001745923,0.0003164966,0.0001365809,0.0001911054,0.0002123615,0.0002018463,0.0005044304,0.00113708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003011812,"about_ca_system_score_gemma":0.0003017655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003442488,"about_ca_topic_score_gemma":0.0003856816,"domain_scores_codex":[0.9996533,0.00008698482,0.00004877797,0.0000480505,0.00007724469,0.00008565699],"domain_scores_gemma":[0.9996659,0.00005256476,0.00009791456,0.00005137232,0.00005270812,0.00007956974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004672869,0.00002805716,0.0004523103,0.00003706135,0.000004211362,0.0002138776,0.00001639362,0.00002348987,0.9979358,0.00004233774,0.00006762178,0.0007117245],"study_design_scores_gemma":[0.00016532,0.001031839,0.04682598,0.00002479893,0.00005552868,0.002822827,0.0001954773,0.001872311,0.9401101,0.0002261092,0.006648071,0.00002166007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924899,0.002288668,0.002954343,0.0003040516,0.00009145267,0.00005816662,0.0007091736,0.0001179619,0.0009863043],"genre_scores_gemma":[0.9958479,0.0005536238,0.001777354,0.0001105799,0.00003030758,0.00007536197,0.0007475714,0.00002206089,0.0008351398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550504,"threshold_uncertainty_score":0.005186915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03158412120413322,"score_gpt":0.2877960489754604,"score_spread":0.2562119277713272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}