{"id":"W2148994398","doi":"10.4049/jimmunol.0902474","title":"Transient Receptor Potential Melastatin 2 Is Required for Lipopolysaccharide-Induced Cytokine Production in Human Monocytes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fraunhofer-Institut für Zelltherapie und Immunologie; Universität Regensburg; Universitetet i Bergen; Deutsche Forschungsgemeinschaft; York University; F. Hoffmann-La Roche; NYU Langone Medical Center","keywords":"TRPM2; Downregulation and upregulation; Monocyte; Transient receptor potential channel; Lipopolysaccharide; Cell biology; Cytokine; Chemistry; Intracellular; Tumor necrosis factor alpha; Receptor; Biology; Biochemistry; Immunology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007991873,0.0001334466,0.0002507735,0.0002188238,0.0002249327,0.00001875588,0.0004105032,0.000121323,0.0001433836],"category_scores_gemma":[0.0004095435,0.00008549068,0.0001178295,0.0001577191,0.0001776135,0.0001939255,0.0000336237,0.000598475,0.000009249281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000357366,"about_ca_system_score_gemma":0.0000583419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003644819,"about_ca_topic_score_gemma":0.00002169631,"domain_scores_codex":[0.9986055,0.0002090583,0.0005607076,0.0001672637,0.0001748437,0.000282551],"domain_scores_gemma":[0.9990992,0.000127732,0.000445896,0.0001627096,0.0001288723,0.00003557638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005250565,0.0001151536,0.000002576108,0.000005163135,0.00001548163,0.00000232331,0.002103344,0.00005554333,0.9924732,0.0001704981,0.0004501655,0.004081424],"study_design_scores_gemma":[0.000936523,0.0007104569,0.00008482319,0.00001970237,0.00002100346,0.0002594456,0.0005352718,0.00007084809,0.9955675,0.0007374036,0.0009618206,0.00009520324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876443,0.00005244198,0.0002509693,0.006351156,0.005381948,0.0002815402,0.000006271932,0.00001243364,0.00001896529],"genre_scores_gemma":[0.998721,0.0001570505,0.0001917136,0.0001283595,0.000545726,0.000007864455,6.618512e-7,0.00001953989,0.0002280561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01107675,"threshold_uncertainty_score":0.3486208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03158412120413322,"score_gpt":0.2877960489754604,"score_spread":0.2562119277713272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}