{"id":"W2149000422","doi":"10.1128/aac.01343-10","title":"Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft","keywords":"Efflux; Candida albicans; Drug resistance; Drug; Transcription (linguistics); Microbiology; Transcription factor; Biology; Pharmacology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427885,0.0004475645,0.0003231412,0.0003362257,0.0002084736,0.0004832849,0.0002881284,0.0002579629,0.0006781904],"category_scores_gemma":[0.000176313,0.000250626,0.000328402,0.0002752594,0.0002546655,0.0001802013,0.0003810381,0.0007123672,0.0003500518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005790251,"about_ca_system_score_gemma":0.0002346183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001559082,"about_ca_topic_score_gemma":0.001104546,"domain_scores_codex":[0.9997159,0.00004031581,0.00003181406,0.00006233311,0.00009008873,0.0000596007],"domain_scores_gemma":[0.9998527,0.00002675263,0.00003834974,0.00002185586,0.00002444374,0.00003590825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005435209,0.00001554219,0.0001072907,0.00001727229,0.000001934666,0.00003372642,0.000008498221,0.00005490631,0.9990496,0.0000368876,0.00002394898,0.0005961786],"study_design_scores_gemma":[0.00001815223,0.00009233596,0.009172949,0.000007954573,0.0000158608,0.0001961959,0.00003934339,0.002445774,0.9866568,0.00004552616,0.001294445,0.00001461658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937975,0.002270542,0.002160403,0.0001079195,0.00002302978,0.00002773614,0.0006727249,0.0001047607,0.0008354422],"genre_scores_gemma":[0.9919897,0.0009895748,0.003448357,0.00007833442,0.0000122838,0.00007829506,0.001226684,0.00004976225,0.002126884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559082,"threshold_uncertainty_score":0.004201174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01647328147509205,"score_gpt":0.2362067818781674,"score_spread":0.2197335004030753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}