{"id":"W2149010016","doi":"10.1161/01.res.0000160709.49633.2b","title":"Mechanisms of Atrial Fibrillation Termination by Pure Sodium Channel Blockade in an Ionically-Realistic Mathematical Model","year":2005,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Heart Institute; Université de Montréal; University of Calgary","funders":"National Heart, Lung, and Blood Institute; Mitacs; American Heart Association","keywords":"Tetrodotoxin; Sodium channel; Blockade; Chemistry; Internal medicine; Potassium channel; Biophysics; Cardiology; Anesthesia; Sodium; Receptor; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008902876,0.00009452568,0.0002664849,0.0002737105,0.00008384758,0.00001474232,0.00006086062,0.0002264542,0.00006525177],"category_scores_gemma":[0.0003750773,0.00009139199,0.0001073283,0.0003216409,0.00009600777,0.0001466865,0.00002860181,0.0003100068,0.00002491913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504967,"about_ca_system_score_gemma":0.0001548526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001014717,"about_ca_topic_score_gemma":0.000008610263,"domain_scores_codex":[0.998314,0.0002118529,0.0003671342,0.0002718379,0.0005463089,0.0002889048],"domain_scores_gemma":[0.9991016,0.0001784023,0.00006632795,0.0002606381,0.000289415,0.000103602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001153558,0.0002740883,0.0008046351,0.0002635076,0.00005970108,0.00002626852,0.0008430778,0.420986,0.5258456,0.03538764,0.0004244775,0.01393146],"study_design_scores_gemma":[0.001149299,0.0001878551,0.006846942,0.00005274596,0.00002314974,0.00003105267,0.00003713932,0.9391949,0.003695542,0.04868671,0.00000793544,0.00008675433],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983561,0.00009900597,0.01341502,0.001692198,0.00002236031,0.0006136506,0.00001186135,0.00002844551,0.000556486],"genre_scores_gemma":[0.9987122,0.00002086393,0.0005126955,0.00002729409,0.0003387658,0.00001421384,0.0001934305,0.00001676779,0.0001637447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.52215,"threshold_uncertainty_score":0.3726857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05021766888511758,"score_gpt":0.3741313922906804,"score_spread":0.3239137234055628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}