{"id":"W2149011125","doi":"10.1158/0008-5472.can-10-4049","title":"Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Pancreatic cancer; Metastasis; Hypoxia (environmental); Cancer research; Medicine; Cancer; Primary tumor; Oncology; Internal medicine; Pathology; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000275033,0.0001808493,0.0003216495,0.0001267222,0.0001555507,0.00002436874,0.0002798261,0.0001618192,0.0002627377],"category_scores_gemma":[0.0001391516,0.0001625517,0.00008523785,0.0001869975,0.0003265563,0.00002531245,0.0002130963,0.0002165811,0.00000213974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004763572,"about_ca_system_score_gemma":0.0002730096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005099189,"about_ca_topic_score_gemma":0.001993276,"domain_scores_codex":[0.9982161,0.0001920077,0.0003156975,0.0004303196,0.0004199148,0.0004259452],"domain_scores_gemma":[0.9988649,0.00004311129,0.0001760003,0.0003760076,0.0003509565,0.0001889971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000538132,0.00007901662,0.002135555,0.0002263454,0.0002210966,0.00003296305,0.001039739,9.904846e-7,0.9787403,0.000111956,0.002922477,0.01395147],"study_design_scores_gemma":[0.001949731,0.0006607628,0.07152224,0.0003062821,0.0002283742,0.00007645257,0.0002806861,0.000006051293,0.9048808,0.0007947367,0.01887798,0.0004159213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720564,0.02546013,0.00006539107,0.0000465204,0.0002896312,0.0004560118,0.0003185395,0.00001219761,0.00129519],"genre_scores_gemma":[0.9740844,0.02364865,0.0003564584,0.0001171476,0.0009878166,0.0003323288,0.0001531111,0.00003238647,0.0002877186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07385948,"threshold_uncertainty_score":0.7708483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0446552823228403,"score_gpt":0.3167526404618016,"score_spread":0.2720973581389613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}