{"id":"W2149041141","doi":"10.1038/sj.clpt.6100125","title":"Identification and Characterization of CYP2D6*56B, an Allele Associated with the Poor Metabolizer Phenotype","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"CYP2D6; Genotype; Allele; Phenotype; Dextromethorphan; Pharmacogenetics; Genetics; Genotype-phenotype distinction; Biology; Allele frequency; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709636,0.000430679,0.0004356441,0.0007797253,0.0004791835,0.000371363,0.000276244,0.0009073582,0.001533223],"category_scores_gemma":[0.001138652,0.0002830561,0.0003129802,0.0003894587,0.0004453025,0.0001882072,0.0002426869,0.0008642186,0.0005799637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001947829,"about_ca_system_score_gemma":0.0001542751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001495024,"about_ca_topic_score_gemma":0.0008547396,"domain_scores_codex":[0.9998265,0.00002432917,0.00001909757,0.00004676341,0.00003779469,0.00004560205],"domain_scores_gemma":[0.999727,0.00008581686,0.0000576577,0.00001877056,0.00002468202,0.00008614469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0008887149,0.0005500437,0.1894779,0.00007711689,0.00004974038,0.6338081,0.00107991,0.0001733782,0.1567638,0.000506745,0.001374375,0.0152501],"study_design_scores_gemma":[0.00009049991,0.000903002,0.2214256,0.00002514067,0.00006258669,0.7538763,0.0004667914,0.0007491242,0.01772284,0.0002103548,0.004443316,0.00002441635],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997703,0.0003094604,0.000469619,0.0004005391,0.00003027729,0.00002825816,0.0001692199,0.00001245312,0.0008771604],"genre_scores_gemma":[0.9979813,0.0003080842,0.0006007775,0.0001580831,0.0000433994,0.000009943439,0.0002202404,0.0000155958,0.0006626441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533223,"threshold_uncertainty_score":0.005129099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1546164401562838,"score_gpt":0.4811678891458,"score_spread":0.3265514489895163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}