{"id":"W2149055857","doi":"10.1158/1078-0432.ccr-14-0624","title":"On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; Research Manitoba","funders":"","keywords":"Nicotinamide phosphoribosyltransferase; Biology; CD38; Chronic lymphocytic leukemia; Fludarabine; NAD+ kinase; Apoptosis; Cancer research; Programmed cell death; Viability assay; Cell biology; Leukemia; Biochemistry; Immunology; Stem cell; CD34; Enzyme; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003891545,0.0003052379,0.000602102,0.000136566,0.00008588761,0.00002991397,0.0007077604,0.0006267288,0.000118783],"category_scores_gemma":[0.00175712,0.00025467,0.000308318,0.0004949481,0.0006143362,0.000005352747,0.0002738945,0.001087941,0.00006318071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001213162,"about_ca_system_score_gemma":0.002158765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009687086,"about_ca_topic_score_gemma":0.00009753992,"domain_scores_codex":[0.9949257,0.001446902,0.0007565785,0.0009996039,0.000854556,0.001016646],"domain_scores_gemma":[0.9974667,0.001031352,0.00007661821,0.0007432092,0.0002244265,0.0004577231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002551086,0.0001342187,0.002052958,0.0002263475,0.00006536911,0.000005029353,0.00000863532,0.0001824086,0.9792086,0.00003672259,0.01132749,0.0042011],"study_design_scores_gemma":[0.004931872,0.00512548,0.0002441485,0.0001695536,0.00001198672,7.270528e-7,0.000003000104,0.001079328,0.9735757,0.0000705797,0.01452973,0.0002579045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955996,0.002574122,0.000131854,0.0001333902,0.0001707644,0.0007220734,0.00009443974,0.00001499468,0.0005588131],"genre_scores_gemma":[0.9962053,0.002285224,0.0000301974,0.0002007749,0.0003356239,0.0002607906,0.0001930073,0.00006164129,0.0004274395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005632952,"threshold_uncertainty_score":0.9999906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02653604199766392,"score_gpt":0.3910419005806626,"score_spread":0.3645058585829987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}