{"id":"W2149055857","doi":"10.1158/1078-0432.ccr-14-0624","title":"On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; Research Manitoba","funders":"","keywords":"Nicotinamide phosphoribosyltransferase; Biology; CD38; Chronic lymphocytic leukemia; Fludarabine; NAD+ kinase; Apoptosis; Cancer research; Programmed cell death; Viability assay; Cell biology; Leukemia; Biochemistry; Immunology; Stem cell; CD34; Enzyme; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007117228,0.0002895049,0.0003625185,0.0001070419,0.0001325356,0.000192574,0.0001310293,0.0001396262,0.001083352],"category_scores_gemma":[0.00006187418,0.00005270638,0.0001930666,0.0001074973,0.0001238749,0.00009676044,0.0001032236,0.0003089097,0.0002704168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798575,"about_ca_system_score_gemma":0.0001510255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006672404,"about_ca_topic_score_gemma":0.00119171,"domain_scores_codex":[0.9999123,0.00001446046,0.00000910904,0.00001853837,0.00002297481,0.00002266091],"domain_scores_gemma":[0.9999597,0.000006276751,0.00001083635,0.000007828234,0.000006810367,0.000008596444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000679386,0.0001448836,0.0008360121,0.00008376061,0.0000109994,0.00006758965,0.00002114385,0.0001497967,0.991969,0.00003597432,0.00008610504,0.005915295],"study_design_scores_gemma":[0.0000582403,0.002626634,0.01023672,0.000008693091,0.00002850801,0.0005250343,0.00002790515,0.0007838084,0.9831743,0.00002231735,0.002503989,0.000003880982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959621,0.001992393,0.0007953548,0.00003865929,0.00001746537,0.00002379015,0.0002291939,0.00004038875,0.0009007734],"genre_scores_gemma":[0.9973704,0.0007197761,0.0005198118,0.00002926019,0.000006041661,0.00002263367,0.0003496029,0.000004447286,0.0009780648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083352,"threshold_uncertainty_score":0.003624141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02653604199766392,"score_gpt":0.3910419005806626,"score_spread":0.3645058585829987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}