{"id":"W2149076892","doi":"10.1110/ps.9.5.956","title":"Crystal structure of the antibiotic albomycin in complex with the outer membrane transporter FhuA","year":2000,"lang":"en","type":"article","venue":"Protein Science","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Medical Research Council; Medical Research Council Canada; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst","keywords":"Siderophore; Bacterial outer membrane; Chemistry; Chelation; Antibiotics; Escherichia coli; Stereochemistry; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892272,0.0001112664,0.0001087467,0.00002042688,0.000103787,0.0000291125,0.0006916327,0.00004845496,0.0001361015],"category_scores_gemma":[0.00001272643,0.00005472493,0.00003494441,0.0003251384,0.00117954,0.000009936399,0.00003954435,0.00008842663,0.000001405306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009548715,"about_ca_system_score_gemma":0.0001099269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004087409,"about_ca_topic_score_gemma":0.0002888599,"domain_scores_codex":[0.9989887,0.00004193019,0.000157646,0.0003021791,0.00027067,0.0002388297],"domain_scores_gemma":[0.9993533,0.00000391848,0.00006826203,0.0004997046,0.0000454028,0.0000294116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006370426,0.00001583604,0.01108985,0.00001553719,0.000003675308,0.000001348583,0.0001088276,0.00006140242,0.9881437,0.00003304186,0.00001959811,0.000443477],"study_design_scores_gemma":[0.0002375716,0.00006420578,0.2619311,0.00003671248,0.000004242009,0.00001327361,0.0000474122,0.00003307614,0.7363345,0.00002222488,0.001183117,0.00009258213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982591,0.00003077776,0.00008273039,0.0004810898,0.00002073576,0.0004372047,0.0000168225,0.000002950334,0.0006686444],"genre_scores_gemma":[0.9986447,0.000004519289,0.000747511,0.0001490456,0.00002735102,0.000001415674,0.000003821578,0.000007992369,0.0004136255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2518092,"threshold_uncertainty_score":0.4346065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007078549415747315,"score_gpt":0.2221474559647972,"score_spread":0.2150689065490499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}