{"id":"W2149113197","doi":"10.1111/j.1750-3639.2001.tb00406.x","title":"Transgenic and Knockout Mouse Models Clarify Pituitary Development, Function and Disease","year":2001,"lang":"en","type":"article","venue":"Brain Pathology","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Biology; Carcinogenesis; Transgene; Knockout mouse; Pituitary tumors; Genetically modified mouse; Oncogene; Cancer research; Hormone; Transcription factor; Conditional gene knockout; Pituitary gland; Cell; Receptor; Endocrinology; Cell cycle; Cancer; Gene; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001330354,0.0001233568,0.00009606584,0.00003858867,0.0001102479,0.00001024288,0.00004488632,0.0002170862,0.000006658523],"category_scores_gemma":[0.00003042893,0.0001178235,0.0000264577,0.00003640833,0.0001033196,0.00000492506,0.00005902087,0.0001014323,0.000003017225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004084614,"about_ca_system_score_gemma":0.00004968592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002161362,"about_ca_topic_score_gemma":0.00001458121,"domain_scores_codex":[0.9991367,0.00005038393,0.0001341056,0.0004509343,0.00004891536,0.0001789731],"domain_scores_gemma":[0.9996226,0.000004490264,0.00003190569,0.0001748874,0.00002945339,0.0001366556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000424166,0.00007978452,0.007393963,0.00002757769,0.0000411488,0.0000194427,0.0001470698,0.0001246929,0.9663704,0.0005363273,0.001041756,0.02379365],"study_design_scores_gemma":[0.005244766,0.002454776,0.6023592,0.00003191578,0.0002512546,0.001182562,0.0004962674,0.001320754,0.06536005,0.01613561,0.3031882,0.001974626],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746096,0.003222269,0.02090536,0.0008443769,0.00007981511,0.0001324865,0.000005452452,0.0000154383,0.0001851989],"genre_scores_gemma":[0.9948989,0.001003603,0.0007811551,0.0008828416,0.00015893,0.00001858768,0.00008057812,0.00001852867,0.002156864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9010103,"threshold_uncertainty_score":0.4804702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445553932866616,"score_gpt":0.2230352492242205,"score_spread":0.2085797098955543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}