{"id":"W2149113197","doi":"10.1111/j.1750-3639.2001.tb00406.x","title":"Transgenic and Knockout Mouse Models Clarify Pituitary Development, Function and Disease","year":2001,"lang":"en","type":"article","venue":"Brain Pathology","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Biology; Carcinogenesis; Transgene; Knockout mouse; Pituitary tumors; Genetically modified mouse; Oncogene; Cancer research; Hormone; Transcription factor; Conditional gene knockout; Pituitary gland; Cell; Receptor; Endocrinology; Cell cycle; Cancer; Gene; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009363475,0.0007440669,0.0006250589,0.001471096,0.0004880858,0.0006853052,0.0006114286,0.001135814,0.003950485],"category_scores_gemma":[0.0006568155,0.0005229326,0.0004347482,0.0007560411,0.0009394658,0.001050607,0.0006160954,0.001948251,0.001096234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003925264,"about_ca_system_score_gemma":0.0006037312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000952635,"about_ca_topic_score_gemma":0.002128311,"domain_scores_codex":[0.9995719,0.0001005272,0.00005784448,0.00007729256,0.0001234452,0.00006912976],"domain_scores_gemma":[0.9995471,0.0001075196,0.0001425584,0.00005961729,0.00005539386,0.00008781152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005964645,0.000225225,0.0008248411,0.0006650661,0.00007103205,0.000898351,0.0002225002,0.0003421515,0.9343045,0.02282499,0.006242427,0.0327825],"study_design_scores_gemma":[0.0005846938,0.002241955,0.01258637,0.0006141884,0.0005822438,0.0156741,0.0003829697,0.003087484,0.4140566,0.01641264,0.5335646,0.0002121296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4488949,0.1047677,0.3647894,0.01089272,0.003497002,0.001544652,0.01516486,0.005973548,0.04447523],"genre_scores_gemma":[0.5219366,0.1376852,0.2711858,0.002457371,0.0007856718,0.002325561,0.01285652,0.0009737379,0.04979346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003950485,"threshold_uncertainty_score":0.01321566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445553932866616,"score_gpt":0.2230352492242205,"score_spread":0.2085797098955543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}