{"id":"W2149116091","doi":"10.1097/01.shk.0000180074.69143.77","title":"IMPLICATION OF TOLL-LIKE RECEPTOR AND TUMOR NECROSIS FACTOR α SIGNALING IN SEPTIC SHOCK","year":2005,"lang":"en","type":"review","venue":"Shock","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"","keywords":"Septic shock; Tumor necrosis factor alpha; TLR4; Sepsis; Lipopolysaccharide; Immunology; Toll-like receptor; Signal transduction; Cytokine; Medicine; Inflammation; Immune system; Proinflammatory cytokine; Biology; Innate immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002374937,0.0003159591,0.001133615,0.0003168376,0.00006301908,0.0000149049,0.000207617,0.0004770224,0.0005776293],"category_scores_gemma":[0.00007491985,0.0002729417,0.0002216313,0.0002115129,0.00008057369,0.0001065805,0.00008200717,0.0003852383,0.0003708295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234519,"about_ca_system_score_gemma":0.000178157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003790246,"about_ca_topic_score_gemma":0.00001089621,"domain_scores_codex":[0.9981403,0.0003249194,0.0008629073,0.0003434958,0.00003664239,0.0002917679],"domain_scores_gemma":[0.9988953,0.0002530564,0.0004544041,0.0003318097,0.00004802968,0.00001734637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005427918,0.00004073893,0.00001525258,0.002188457,0.0001439008,8.923877e-7,0.0002570724,5.596436e-7,0.03616002,0.00005456931,0.0005802324,0.960504],"study_design_scores_gemma":[0.0003643204,0.00008826354,0.0000561751,0.002925887,0.0001660224,0.00005018467,0.00004339806,0.000001179944,0.005340281,0.00001162571,0.990658,0.0002946546],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01142252,0.9873955,0.00001437709,0.00002509269,0.0002592533,0.0006619945,0.00005422031,0.00003059578,0.0001364499],"genre_scores_gemma":[0.002720009,0.9951128,0.0001003135,0.00002052065,0.00004467794,0.00006298859,0.0004047879,0.00003793977,0.00149601],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9900778,"threshold_uncertainty_score":0.9999723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02604900176854874,"score_gpt":0.2970014441831835,"score_spread":0.2709524424146348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}