{"id":"W2149116091","doi":"10.1097/01.shk.0000180074.69143.77","title":"IMPLICATION OF TOLL-LIKE RECEPTOR AND TUMOR NECROSIS FACTOR α SIGNALING IN SEPTIC SHOCK","year":2005,"lang":"en","type":"review","venue":"Shock","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"","keywords":"Septic shock; Tumor necrosis factor alpha; TLR4; Sepsis; Lipopolysaccharide; Immunology; Toll-like receptor; Signal transduction; Cytokine; Medicine; Inflammation; Immune system; Proinflammatory cytokine; Biology; Innate immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003582961,0.0006160996,0.0008303333,0.001206213,0.0002617195,0.0006965001,0.0006772407,0.0009441665,0.002410474],"category_scores_gemma":[0.0004448559,0.0001752272,0.0002333251,0.001300778,0.0003320616,0.001218147,0.0003791931,0.001024171,0.002758618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005481505,"about_ca_system_score_gemma":0.0008663544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005765436,"about_ca_topic_score_gemma":0.0008299525,"domain_scores_codex":[0.9998752,0.00002116153,0.00001888813,0.00001943469,0.00005295009,0.00001240629],"domain_scores_gemma":[0.9998227,0.00005350378,0.00002734411,0.000004786787,0.00006376403,0.00002804813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001511247,0.00007961158,0.0002609231,0.008652703,0.000055113,0.0005018837,0.00007189153,0.0003502746,0.005022443,0.003431178,0.02565447,0.9557684],"study_design_scores_gemma":[0.00002401344,0.0001509046,0.001177625,0.001371534,0.00005268875,0.002374756,0.0000940642,0.00008424313,0.001115788,0.001998588,0.9915417,0.00001401417],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002046409,0.9979274,0.0001547053,0.0002095744,0.0002930306,0.000003039957,0.000006942893,0.000007192103,0.001193388],"genre_scores_gemma":[0.001077389,0.9972116,0.0001850618,0.0001865861,0.0001856339,0.000004964549,0.00001611698,9.539253e-7,0.001131591],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002410474,"threshold_uncertainty_score":0.008063853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02604900176854874,"score_gpt":0.2970014441831835,"score_spread":0.2709524424146348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}