{"id":"W2149150109","doi":"10.1126/scisignal.2004145","title":"Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses","year":2013,"lang":"en","type":"article","venue":"Science Signaling","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; Phenotype; Transcription factor; Function (biology); Transcription (linguistics); Genetics; Yeast; Ribosomal RNA; Saccharomyces cerevisiae; Ribosomal DNA; DNA; Nucleolus; Cell biology; Computational biology; Gene; Evolutionary biology; Phylogenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017409,0.0002652477,0.000186649,0.000411787,0.0001520108,0.0003072526,0.000187561,0.0001587337,0.0007092174],"category_scores_gemma":[0.00014995,0.000125635,0.0001638152,0.0002165259,0.0001993984,0.000168092,0.0002205666,0.0002779679,0.0002079644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570488,"about_ca_system_score_gemma":0.0001100204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004494144,"about_ca_topic_score_gemma":0.0009129764,"domain_scores_codex":[0.9999096,0.000008226187,0.000005221797,0.00003778356,0.00002450552,0.00001457753],"domain_scores_gemma":[0.9998646,0.0000202212,0.00005321296,0.00001928547,0.00002049929,0.0000222589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002200633,0.000003539364,0.0006144945,0.000006702667,0.000003662909,0.00001026676,0.000003107351,0.00004645023,0.9985552,0.00004344797,0.000009645371,0.0006814634],"study_design_scores_gemma":[0.00001055479,0.0001205004,0.1095397,0.000004512312,0.00004840453,0.0003703904,0.0000413823,0.003190967,0.8844447,0.0002497043,0.001967104,0.00001206496],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860256,0.00107374,0.009896293,0.00005540276,0.000008117135,0.00002585368,0.001185973,0.0002012025,0.001527875],"genre_scores_gemma":[0.9921792,0.0004303057,0.005138815,0.00004748846,0.000005934917,0.00003685708,0.001281291,0.00006471445,0.0008155291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007092174,"threshold_uncertainty_score":0.002372503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015263328464335,"score_gpt":0.2650801044044376,"score_spread":0.2549274711197942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}