{"id":"W2149150109","doi":"10.1126/scisignal.2004145","title":"Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses","year":2013,"lang":"en","type":"article","venue":"Science Signaling","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; Phenotype; Transcription factor; Function (biology); Transcription (linguistics); Genetics; Yeast; Ribosomal RNA; Saccharomyces cerevisiae; Ribosomal DNA; DNA; Nucleolus; Cell biology; Computational biology; Gene; Evolutionary biology; Phylogenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002998337,0.0001072053,0.0001367579,0.00002062062,0.0001255599,0.0000510461,0.0003995695,0.00006368676,0.00007270183],"category_scores_gemma":[0.0001791667,0.00009852167,0.0000669462,0.0003069968,0.0003956062,0.000009480873,0.0001177285,0.00003573956,0.00000864116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002476115,"about_ca_system_score_gemma":0.000150106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001180952,"about_ca_topic_score_gemma":0.000006041076,"domain_scores_codex":[0.9989755,0.00002702652,0.000236054,0.0003075272,0.0001979021,0.0002559509],"domain_scores_gemma":[0.999254,0.00001329163,0.000139111,0.0003036243,0.0001902499,0.00009967514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004406564,0.00001693898,0.007077383,0.000008669162,0.00001313006,1.557106e-7,0.00001712296,0.0002890943,0.9918898,0.00008117745,0.0003297558,0.0002723584],"study_design_scores_gemma":[0.0003225031,0.0001169184,0.01564367,0.00002058022,0.00002082258,0.000004545805,0.0002873646,0.002868633,0.9789062,0.001435527,0.000147925,0.0002253127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998257,0.0003719748,0.0005945988,0.00005732525,0.00006791447,0.0001091734,0.00001831576,0.000007461396,0.000516176],"genre_scores_gemma":[0.9954219,0.00001281154,0.004300252,0.000120906,0.00002734145,0.000003967262,0.000009718287,0.000007013566,0.00009602762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01298361,"threshold_uncertainty_score":0.4017597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015263328464335,"score_gpt":0.2650801044044376,"score_spread":0.2549274711197942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}