{"id":"W2149168973","doi":"10.1128/aac.49.5.1727-1732.2005","title":"Immunomodulatory Activities of Small Host Defense Peptides","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":312,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Cathelicidin; Lipopolysaccharide; Biology; Chemokine; Antimicrobial peptides; Tumor necrosis factor alpha; Innate immune system; Monocyte; Interleukin 8; Proinflammatory cytokine; Chemotaxis; Cell culture; Cytokine; Secretion; Microbiology; In vitro; Cell biology; Peptide; Biochemistry; Immune system; Inflammation; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001176121,0.000289724,0.0004418416,0.0001079552,0.0002128446,0.00003351165,0.0001899832,0.0002103503,0.0005180159],"category_scores_gemma":[0.000005938824,0.0002617305,0.0001728386,0.00007633372,0.000520236,0.0001917627,0.00007907513,0.0001975454,0.00005916534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002297226,"about_ca_system_score_gemma":0.00003746022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001945775,"about_ca_topic_score_gemma":0.00003943629,"domain_scores_codex":[0.9988494,0.00005630963,0.0003473313,0.000324006,0.00003105763,0.0003918906],"domain_scores_gemma":[0.9994311,0.00005357673,0.0001984013,0.0002468664,0.00004328319,0.00002676606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002822098,0.0003318743,0.006783093,0.00005875945,0.0003178398,0.00000201686,0.001443034,0.000007911351,0.9460933,0.0003688847,0.02441094,0.01990015],"study_design_scores_gemma":[0.002374502,0.000178268,0.02861119,0.0001214348,0.00005390873,0.00009535583,0.000476435,0.000007681737,0.8402801,0.00003436953,0.1272883,0.0004784826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967638,0.0004036531,0.00009169343,0.0009288897,0.0002217983,0.0001849629,0.00007101565,0.00006135127,0.001272821],"genre_scores_gemma":[0.9907016,0.001483203,0.000726282,0.003101796,0.00009166821,0.00000365217,0.00003494234,0.00004022595,0.003816658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1058132,"threshold_uncertainty_score":0.9999835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176822518590607,"score_gpt":0.2200420647538059,"score_spread":0.2082738395678998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}