{"id":"W2149168973","doi":"10.1128/aac.49.5.1727-1732.2005","title":"Immunomodulatory Activities of Small Host Defense Peptides","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":312,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Cathelicidin; Lipopolysaccharide; Biology; Chemokine; Antimicrobial peptides; Tumor necrosis factor alpha; Innate immune system; Monocyte; Interleukin 8; Proinflammatory cytokine; Chemotaxis; Cell culture; Cytokine; Secretion; Microbiology; In vitro; Cell biology; Peptide; Biochemistry; Immune system; Inflammation; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604424,0.0002992715,0.0001970711,0.0001833439,0.00007961727,0.0002482604,0.0001163425,0.000187835,0.00129449],"category_scores_gemma":[0.0001959641,0.0000641495,0.0001392849,0.0001051102,0.0001807771,0.000191845,0.000166469,0.0002919504,0.0001599228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001094089,"about_ca_system_score_gemma":0.0000873501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007090328,"about_ca_topic_score_gemma":0.00006020791,"domain_scores_codex":[0.9999044,0.00002559114,0.000006359036,0.00001741704,0.00002167501,0.00002454583],"domain_scores_gemma":[0.9998772,0.00003551435,0.00002441324,0.00001071177,0.00001557765,0.00003644048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003537652,0.00003628559,0.0002433762,0.00007553218,0.000005603236,0.0000822589,0.000008833736,0.00009394808,0.9923768,0.00005048163,0.00001680388,0.006656347],"study_design_scores_gemma":[0.0001213082,0.006117722,0.01104382,0.00002929143,0.00003936304,0.001126147,0.00004384536,0.0008233155,0.9728782,0.0001759831,0.007588656,0.00001240676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898778,0.007760082,0.0007690522,0.00004360929,0.00002779633,0.00002789645,0.00008873543,0.00001786531,0.001387273],"genre_scores_gemma":[0.996046,0.001779409,0.00127176,0.00006057303,0.00004145521,0.00002728752,0.0001411042,0.000003464765,0.0006289991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129449,"threshold_uncertainty_score":0.004330516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176822518590607,"score_gpt":0.2200420647538059,"score_spread":0.2082738395678998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}