{"id":"W2149189186","doi":"10.1074/jbc.m802595200","title":"Contribution of Each Membrane Binding Domain of the CTP:Phosphocholine Cytidylyltransferase-α Dimer to Its Activation, Membrane Binding, and Membrane Cross-bridging","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Phosphocholine; Membrane; Dimer; Biophysics; Chemistry; Bridging (networking); Biochemistry; Cell biology; Biology; Phospholipid; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404173,0.0003094114,0.0002529899,0.00008243244,0.0001315856,0.000248588,0.0001816509,0.0002545032,0.0006733939],"category_scores_gemma":[0.0001951627,0.0001556068,0.0001985441,0.00008164948,0.0002070861,0.0001582805,0.0002076284,0.0005890126,0.0003260728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940996,"about_ca_system_score_gemma":0.0001906275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002728808,"about_ca_topic_score_gemma":0.0002152446,"domain_scores_codex":[0.9998716,0.00003014909,0.00001451799,0.00003375244,0.00003180287,0.00001804721],"domain_scores_gemma":[0.9998424,0.0000291833,0.00002896136,0.00002287547,0.00002293655,0.00005371205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001297839,0.00001790043,0.0003492621,0.00001344601,0.000003312437,0.00003281252,0.000008486868,0.00005984954,0.9985934,0.00006934952,0.00001085046,0.0007116076],"study_design_scores_gemma":[0.00003169681,0.0001320778,0.004148629,0.000006447512,0.00001810886,0.0004781985,0.00003004347,0.002517792,0.9913746,0.00005792797,0.001198866,0.000005677837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963298,0.0005507765,0.002508235,0.00004984445,0.00001567396,0.00001143766,0.00004665181,0.0000105397,0.0004770459],"genre_scores_gemma":[0.9973131,0.0001697893,0.001463176,0.00004018521,0.000006772052,0.00001529799,0.0002138429,0.000007289239,0.0007705138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006733939,"threshold_uncertainty_score":0.002252698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969641358846852,"score_gpt":0.2639746306221267,"score_spread":0.2442782170336582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}