{"id":"W2149218172","doi":"10.1096/fj.01-0343fje","title":"Selection of phage‐displayed llama single‐domain antibodies that transmigrate across human blood‐brain barrier endothelium","year":2001,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"","keywords":"Phage display; Blood–brain barrier; Single-domain antibody; Antibody; Biology; Molecular biology; Virology; Peptide library; Gene; Immunology; Peptide sequence; Genetics; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001154075,0.0002561141,0.0004417732,0.0001380579,0.0008166322,0.00008893541,0.0002798072,0.0001028354,0.001114797],"category_scores_gemma":[0.00005873103,0.0001544418,0.0003496337,0.0002890844,0.0004278102,0.0001456772,0.00004747798,0.0007514537,0.00002594739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004751306,"about_ca_system_score_gemma":0.00009481355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001402379,"about_ca_topic_score_gemma":0.0001692746,"domain_scores_codex":[0.9976067,0.0002460979,0.0004718648,0.0002172628,0.0007765607,0.0006814981],"domain_scores_gemma":[0.9988932,0.0002050318,0.0002129081,0.0002163052,0.0001957659,0.0002768147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001070516,0.0002784249,0.05532733,0.0000647653,0.0003667574,0.0003579445,0.002027508,0.000006322997,0.937314,0.0001619938,0.0008784722,0.002145953],"study_design_scores_gemma":[0.003403934,0.001345191,0.03874027,0.0002480684,0.0001750436,0.008596768,0.001521008,0.00009492062,0.9376009,0.0008864835,0.007149623,0.0002377564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991693,0.0007169996,0.000253298,0.003710855,0.0001366342,0.0002499278,0.00005794807,0.00002919877,0.003152158],"genre_scores_gemma":[0.9874379,0.0005686454,0.0003322721,0.0004724678,0.0006836243,0.000004722351,0.00001517804,0.00003502746,0.01045017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01658706,"threshold_uncertainty_score":0.9997983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03652082814853694,"score_gpt":0.3237264385664014,"score_spread":0.2872056104178644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}