{"id":"W2149270146","doi":"10.1111/j.1399-0004.2009.01328.x","title":"Does family history predict the age at onset of new breast cancers in <i>BRCA1</i> and <i>BRCA2</i> mutation‐positive families?","year":2009,"lang":"en","type":"article","venue":"Clinical Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; London Health Sciences Centre; Women's College Hospital; University of Toronto; Mount Sinai Hospital","funders":"Canadian Breast Cancer Research Alliance; Breast Cancer Alliance","keywords":"Family history; Breast cancer; Pedigree chart; Medicine; Age of onset; BRCA mutation; Cancer; Oncology; Index case; Internal medicine; Gynecology; Disease; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006801774,0.000223576,0.0002128677,0.0006444124,0.0002336646,0.0003956244,0.0002411187,0.0004253873,0.00171594],"category_scores_gemma":[0.006939644,0.0001650598,0.0002751015,0.0005124161,0.0003654449,0.0003146761,0.0001524998,0.0002554432,0.0002795577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010284,"about_ca_system_score_gemma":0.0005429824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04749807,"about_ca_topic_score_gemma":0.07340749,"domain_scores_codex":[0.9997311,0.0001060111,0.00001924419,0.000039511,0.00005366117,0.00005058028],"domain_scores_gemma":[0.9966277,0.001476429,0.00106951,0.0001286219,0.0002614011,0.0004363398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003333286,0.000005071206,0.998478,0.000002855741,0.00001219391,0.00006488798,0.00003160138,0.00002844939,0.00009148063,0.000004232038,0.00004573902,0.00120226],"study_design_scores_gemma":[0.000002447026,0.00004655596,0.9989991,0.000006624048,0.00002511206,0.0003910987,0.00007303612,0.0002474926,0.00005290384,0.00001667366,0.0001369608,0.000002037369],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975387,0.00109731,0.000129982,0.0001704888,0.000009180938,0.00000410184,0.0001668229,0.000006090156,0.0008773656],"genre_scores_gemma":[0.9992626,0.0003181254,0.00009957758,0.00001805532,0.00000976628,0.000001240393,0.0001168198,0.0000020055,0.0001718305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04749807,"threshold_uncertainty_score":0.0944432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02053264546778915,"score_gpt":0.3002750000600059,"score_spread":0.2797423545922167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}