{"id":"W2149307998","doi":"10.1158/0008-5472.can-09-3108","title":"Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Tamoxifen; Breast cancer; Cancer research; Insulin-like growth factor-binding protein; Cancer; Insulin resistance; Biology; Growth factor; Insulin-like growth factor; Oncology; Internal medicine; Medicine; Bioinformatics; Insulin; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522771,0.0002352861,0.0002466734,0.0004156206,0.0001645773,0.0001712875,0.0002207475,0.0002688748,0.001541759],"category_scores_gemma":[0.0001905419,0.0001202082,0.000267208,0.0002343525,0.0001206623,0.00004764347,0.000107717,0.0002599211,0.0002683344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588382,"about_ca_system_score_gemma":0.0002056051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00122294,"about_ca_topic_score_gemma":0.002468049,"domain_scores_codex":[0.9998991,0.00002386866,0.000008012311,0.00001328917,0.00003463813,0.00002098356],"domain_scores_gemma":[0.9999257,0.00002710814,0.00001556746,0.000005939407,0.000007749566,0.00001782044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001593756,0.00007316514,0.0007634464,0.00001997673,0.00001405572,0.0002155342,0.000006770706,0.00006393638,0.9967775,0.00004821387,0.00008568093,0.001772474],"study_design_scores_gemma":[0.000100079,0.002616612,0.03389139,0.0000122788,0.0001946064,0.002085172,0.00005485122,0.003223507,0.9530629,0.00005546837,0.0046905,0.00001265231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935257,0.001049357,0.002411954,0.0002329371,0.00002977699,0.00009080657,0.0006099144,0.0001425401,0.001907107],"genre_scores_gemma":[0.9942901,0.0006719853,0.002154225,0.0001255431,0.000007097068,0.00002829972,0.0008401784,0.00001644326,0.001866127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001541759,"threshold_uncertainty_score":0.005157709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0389957551018218,"score_gpt":0.3469398326980147,"score_spread":0.3079440775961929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}