{"id":"W2149318226","doi":"10.1073/pnas.0509227103","title":"Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":314,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute on Aging; School of Medicine, New York University; National Institutes of Health; York University; Muscular Dystrophy Association; Parkinson's Disease Foundation; Naito Foundation; U.S. Department of Defense","keywords":"SOD1; Endoplasmic reticulum; Unfolded protein response; Mutant; Cell biology; Superoxide dismutase; Biology; Chaperone (clinical); Transgene; Protein folding; Protein aggregation; Genetically modified mouse; Biochemistry; Oxidative stress; Gene; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165013,0.0007074027,0.0003439863,0.000546553,0.0004237343,0.0002907299,0.0003117791,0.0005273472,0.001672682],"category_scores_gemma":[0.0001170701,0.000190709,0.0002628283,0.0002211408,0.0005964783,0.0002624429,0.0002271822,0.001117178,0.0004329421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006929811,"about_ca_system_score_gemma":0.0003927411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198546,"about_ca_topic_score_gemma":0.002018989,"domain_scores_codex":[0.9998796,0.00002315305,0.00001313136,0.00002631548,0.00003554042,0.00002230377],"domain_scores_gemma":[0.99984,0.00001136121,0.00004982918,0.00002234905,0.00001806548,0.00005831485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004982711,0.0003138837,0.0005953725,0.00007435878,0.00002559337,0.0008693195,0.00004442699,0.0001359744,0.9951806,0.0003187701,0.00019774,0.001745668],"study_design_scores_gemma":[0.0003365696,0.006133606,0.01448519,0.00007878609,0.0001354043,0.005951754,0.0001460121,0.003928674,0.9628913,0.0005673313,0.005325289,0.0000200408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958353,0.0005873413,0.001521056,0.000296078,0.00006162447,0.00006277617,0.0001655886,0.0001615179,0.001308714],"genre_scores_gemma":[0.9926288,0.0007506611,0.001634212,0.00009381444,0.0000172961,0.00006647524,0.0003231837,0.00002263333,0.004462833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672682,"threshold_uncertainty_score":0.005595684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1058720945156663,"score_gpt":0.3798361546143213,"score_spread":0.273964060098655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}