{"id":"W2149345837","doi":"10.1002/ana.21063","title":"A second major histocompatibility complex susceptibility locus for multiple sclerosis","year":2007,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institutes of Health; Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Wellcome Trust; Multiple Sclerosis Society; Cambridge Philosophical Society; Cambridge Commonwealth Trust; GlaxoSmithKline; National Institute of Neurological Disorders and Stroke; Medical Research Council; Cancer Research Institute","keywords":"Genetics; Human leukocyte antigen; Linkage disequilibrium; Locus (genetics); Major histocompatibility complex; Allele; Biology; Genotyping; Multiple sclerosis; Haplotype; Gene; Single-nucleotide polymorphism; Microsatellite; Immunology; Genotype; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001692315,0.0002284601,0.0007797871,0.000205368,0.0001350622,0.000005978662,0.0002191125,0.0001603873,0.0004965735],"category_scores_gemma":[0.002622435,0.000205568,0.0003223735,0.000218894,0.0007041833,0.00006296713,0.0001701092,0.0002964975,0.00001633445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002522892,"about_ca_system_score_gemma":0.00006657602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002009767,"about_ca_topic_score_gemma":0.002565475,"domain_scores_codex":[0.9973727,0.0001454324,0.0007396587,0.0006318156,0.000333503,0.0007768927],"domain_scores_gemma":[0.9961178,0.00185658,0.0002092423,0.0007378808,0.0008044213,0.0002740703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01027547,0.001547684,0.3727263,0.0008051534,0.0002356798,0.00001693839,0.0003487638,0.000006630343,0.5550455,0.00008709897,0.03446752,0.0244373],"study_design_scores_gemma":[0.002939465,0.002491786,0.938839,0.00001544161,0.00002335592,0.000007809766,0.0000284555,0.0004115693,0.03506971,0.0002048682,0.01983551,0.0001330589],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901326,0.0001593341,0.0006422297,0.005798268,0.0001212161,0.001967461,0.0001747713,0.00006606435,0.0009380183],"genre_scores_gemma":[0.9952428,0.00004376556,0.001150194,0.00317359,0.0001461389,0.00007662023,0.00003793301,0.00002854558,0.0001004267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5661127,"threshold_uncertainty_score":0.8382822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.301631256925832,"score_gpt":0.4023348705630437,"score_spread":0.1007036136372117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}