{"id":"W2149352515","doi":"10.1128/ec.00004-15","title":"Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis","year":2015,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Biology; Histone acetyltransferase; Histone; Chromatin immunoprecipitation; Chromatin; Acetyltransferase; RNA polymerase II; Cell biology; Transcription factor; Regulation of gene expression; Chromatin remodeling; Promoter; Gene expression; Gene; Molecular biology; Acetylation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962402,0.0000990559,0.000108462,0.00002879237,0.00004451559,0.00001334574,0.0001139277,0.00009765938,0.00001260322],"category_scores_gemma":[0.00002805853,0.00008168445,0.0000328371,0.00006879256,0.00006038394,0.000002635407,0.00006560994,0.00005323246,0.0000070166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001614304,"about_ca_system_score_gemma":0.00005093698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003579535,"about_ca_topic_score_gemma":0.00005689007,"domain_scores_codex":[0.9993932,0.00003951952,0.0001911739,0.0001738555,0.00009738486,0.0001048955],"domain_scores_gemma":[0.9994767,0.00001204135,0.00007003847,0.0002795155,0.00007998296,0.00008172818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008080442,0.00008924273,0.002789221,0.00003866303,0.00001799803,6.962421e-7,0.0003509052,0.001527574,0.9901803,0.0001740135,0.003177859,0.001572763],"study_design_scores_gemma":[0.001716134,0.001034758,0.1266265,0.00002887534,0.0001076445,0.00002533659,0.0004540592,0.01340829,0.8427172,0.001028365,0.01233395,0.0005188934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933225,0.0002158465,0.004055966,0.0006725663,0.00006876772,0.0002077544,0.00001997493,0.000005816048,0.001430793],"genre_scores_gemma":[0.9956233,0.00003661171,0.003338722,0.0001249979,0.00007510304,0.000005441507,0.0001100458,0.00001399922,0.0006718094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.147463,"threshold_uncertainty_score":0.3330995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576438543407074,"score_gpt":0.2304381072292851,"score_spread":0.2146737217952143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}