{"id":"W2149352515","doi":"10.1128/ec.00004-15","title":"Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis","year":2015,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Biology; Histone acetyltransferase; Histone; Chromatin immunoprecipitation; Chromatin; Acetyltransferase; RNA polymerase II; Cell biology; Transcription factor; Regulation of gene expression; Chromatin remodeling; Promoter; Gene expression; Gene; Molecular biology; Acetylation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266091,0.0005619649,0.0004069099,0.0004888528,0.0005843972,0.001216347,0.000660789,0.0008434966,0.003242389],"category_scores_gemma":[0.0003040379,0.0002895424,0.0004907683,0.0002659817,0.0004281074,0.0009847127,0.0008169875,0.001047711,0.001809903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007717502,"about_ca_system_score_gemma":0.0003942962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002072089,"about_ca_topic_score_gemma":0.002370001,"domain_scores_codex":[0.9998086,0.00001442158,0.00001099207,0.00007528446,0.00003483401,0.00005597933],"domain_scores_gemma":[0.9998597,0.00001684658,0.00003572443,0.00002120326,0.00002548661,0.00004094503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004387252,0.000079666,0.003516316,0.000160603,0.00002230095,0.0003531621,0.00007499525,0.0006203371,0.9809279,0.0008772822,0.0006090925,0.01231952],"study_design_scores_gemma":[0.00002856846,0.0001136243,0.02833668,0.00002359886,0.0000299983,0.0005429772,0.0001274762,0.0066915,0.9487839,0.0006645721,0.01463592,0.00002120648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637372,0.01249146,0.01623992,0.001541612,0.000453125,0.0000372695,0.001300803,0.0003891237,0.003809421],"genre_scores_gemma":[0.9744844,0.003630822,0.005445517,0.0003665476,0.00009180712,0.00003251626,0.002386048,0.0001378649,0.01342455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003242389,"threshold_uncertainty_score":0.01084691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576438543407074,"score_gpt":0.2304381072292851,"score_spread":0.2146737217952143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}