{"id":"W2149358180","doi":"10.1152/ajpendo.00436.2013","title":"FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress","year":2014,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"NADPH oxidase; Oxidative stress; Insulin resistance; In vivo; Internal medicine; Endocrinology; Oxidative phosphorylation; Chemistry; Protein kinase C; Insulin; Biochemistry; Enzyme; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002638003,0.0004872042,0.0002635146,0.0003138713,0.0001449013,0.0002170509,0.000162755,0.0002422206,0.00129971],"category_scores_gemma":[0.000113539,0.0002347219,0.0003494913,0.0002160102,0.0002902297,0.0003124936,0.0002307352,0.000640846,0.0002430103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002046833,"about_ca_system_score_gemma":0.0001944596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005306671,"about_ca_topic_score_gemma":0.0004948211,"domain_scores_codex":[0.999874,0.00002142333,0.00001415226,0.00003152562,0.00002499534,0.00003388258],"domain_scores_gemma":[0.9998738,0.000009525291,0.00004858507,0.00002214621,0.00001366313,0.0000322076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001758068,0.00008216535,0.0009868455,0.00006845246,0.00001763381,0.00009452197,0.00001912253,0.00004247886,0.9940835,0.0001029557,0.00003210432,0.002712048],"study_design_scores_gemma":[0.0001636221,0.001213868,0.02919587,0.00002645441,0.00008397241,0.0007060051,0.00009109105,0.001050458,0.9659104,0.0002903206,0.00125579,0.00001211426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855054,0.005255095,0.007280734,0.0002491373,0.00008959753,0.00005768187,0.0001867387,0.00008408774,0.001291501],"genre_scores_gemma":[0.9920699,0.002872493,0.002924467,0.00009121245,0.0000336478,0.00006077334,0.0002121999,0.00001640326,0.001718697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129971,"threshold_uncertainty_score":0.00434798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008515211774400833,"score_gpt":0.2569759137582543,"score_spread":0.2484607019838535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}