{"id":"W2149363016","doi":"10.1016/j.antiviral.2009.07.005","title":"Targeted delivery of anti-coxsackievirus siRNAs using ligand-conjugated packaging RNAs","year":2009,"lang":"en","type":"article","venue":"Antiviral Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; St. Paul's Hospital","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; National Institute of General Medical Sciences; Heart and Stroke Foundation of Canada","keywords":"Small interfering RNA; HeLa; Folate receptor; RNA; Biology; Ligand (biochemistry); Coxsackievirus; Gene silencing; Viral replication; Chemistry; In vitro; Molecular biology; Cell biology; Virology; Receptor; Virus; Biochemistry; Cancer cell; Gene; Enterovirus; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006539763,0.0001735237,0.0002479852,0.0002028118,0.0001537052,0.00005147834,0.0003715108,0.0001782613,0.00001072167],"category_scores_gemma":[0.0001529918,0.0001638024,0.000135305,0.0003779375,0.0001964665,0.0000198161,0.0001570707,0.0002669968,0.00004342707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001965808,"about_ca_system_score_gemma":0.0001879587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001959593,"about_ca_topic_score_gemma":0.00001575507,"domain_scores_codex":[0.9981013,0.0001894758,0.0003090973,0.0004238246,0.0004024121,0.0005739201],"domain_scores_gemma":[0.9989019,0.00002925009,0.00008050409,0.0004220844,0.0005022904,0.00006397525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001624492,0.0000919362,0.003119219,0.00001304955,0.00004633066,0.00002640373,0.00004590497,0.00001379126,0.9894703,0.00004186791,0.001061763,0.005906963],"study_design_scores_gemma":[0.0003835706,0.000652168,0.005793734,0.00006950589,0.00001000232,0.00000768379,0.0001120781,0.000421105,0.9913793,0.0001334975,0.0008522496,0.0001851582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965053,0.001211714,0.0001595948,0.0001066356,0.00007909046,0.0001723956,0.00001661206,0.00001257656,0.001736034],"genre_scores_gemma":[0.9981212,0.0008583397,0.0001934431,0.0001404181,0.0001748446,0.000002036871,0.00004942746,0.00001917029,0.0004411392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005721804,"threshold_uncertainty_score":0.6679668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06344989725394086,"score_gpt":0.3639606113438208,"score_spread":0.3005107140898799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}