{"id":"W2149363016","doi":"10.1016/j.antiviral.2009.07.005","title":"Targeted delivery of anti-coxsackievirus siRNAs using ligand-conjugated packaging RNAs","year":2009,"lang":"en","type":"article","venue":"Antiviral Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; St. Paul's Hospital","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; National Institute of General Medical Sciences; Heart and Stroke Foundation of Canada","keywords":"Small interfering RNA; HeLa; Folate receptor; RNA; Biology; Ligand (biochemistry); Coxsackievirus; Gene silencing; Viral replication; Chemistry; In vitro; Molecular biology; Cell biology; Virology; Receptor; Virus; Biochemistry; Cancer cell; Gene; Enterovirus; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006117352,0.0004811383,0.0003275384,0.0002940595,0.000335799,0.0005889662,0.0003295247,0.0005130718,0.001247308],"category_scores_gemma":[0.0002172308,0.0003020381,0.000298452,0.0002026853,0.0003248788,0.0003056483,0.0002568276,0.0005906356,0.0004732747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006722381,"about_ca_system_score_gemma":0.0003963569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004827156,"about_ca_topic_score_gemma":0.001189389,"domain_scores_codex":[0.9997367,0.00005177353,0.0000297252,0.00006152928,0.00005705036,0.00006314472],"domain_scores_gemma":[0.9998486,0.00005235412,0.00003611034,0.00001882357,0.00001850028,0.00002561928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006371758,0.00001513926,0.00003468744,0.00002789879,0.000003752877,0.00002792655,0.00001962354,0.00006954237,0.9984571,0.0003724348,0.00004279106,0.0008653578],"study_design_scores_gemma":[0.00001095095,0.0000665434,0.0001471579,0.000001787457,0.000006630619,0.00003676183,0.000005566527,0.0005550675,0.9983216,0.0000273822,0.0008181782,0.000002298616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688806,0.0014391,0.02555774,0.0001944495,0.0000891761,0.0001347252,0.0003003841,0.0003102239,0.003093494],"genre_scores_gemma":[0.9775732,0.0008078225,0.01504369,0.0001103973,0.0000205723,0.0001144001,0.0004941083,0.00007122101,0.005764522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001247308,"threshold_uncertainty_score":0.004877448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06344989725394086,"score_gpt":0.3639606113438208,"score_spread":0.3005107140898799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}