{"id":"W2149401378","doi":"10.1093/hmg/ddv159","title":"Progressive postnatal decline in leptin sensitivity of arcuate hypothalamic neurons in the<i>Magel2</i>-null mouse model of Prader–Willi syndrome","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"National Institutes of Health","keywords":"Leptin; Endocrinology; Internal medicine; Biology; Hypothalamus; Appetite; Leptin receptor; Obesity; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007039347,0.000269961,0.0003578888,0.0001420071,0.00002913882,0.00001909344,0.0003914623,0.0001783646,0.000002377545],"category_scores_gemma":[0.0001603776,0.0002570811,0.0001317132,0.0001912796,0.0002201353,0.000004905397,0.0003844792,0.0002099313,0.00000183266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001594275,"about_ca_system_score_gemma":0.0001377099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008900644,"about_ca_topic_score_gemma":0.000121935,"domain_scores_codex":[0.9977944,0.0003641079,0.0006056835,0.0004547836,0.0003739641,0.0004070322],"domain_scores_gemma":[0.9987352,0.0000222992,0.0002813363,0.0007218365,0.0001509992,0.0000882645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006879967,0.0002552363,0.01145905,0.00004866437,0.00002542143,0.00007568631,0.0003367496,0.02527976,0.9622103,0.00004195572,0.00001481664,0.0002454832],"study_design_scores_gemma":[0.002858869,0.001590472,0.2086463,0.0001005322,0.00007176964,0.000837344,0.000601235,0.01818849,0.7656372,0.0007384383,0.00005965673,0.0006697073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997028,0.0008341564,0.001335317,0.00009438438,0.0000310538,0.0004884297,0.00003948504,0.000005988217,0.0001431644],"genre_scores_gemma":[0.9963135,0.00004127535,0.003320981,0.0001233318,0.00001999415,0.00002021019,0.00006992747,0.00004864884,0.00004210737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1971873,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03024611926069865,"score_gpt":0.2715109135179633,"score_spread":0.2412647942572647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}