{"id":"W2149406788","doi":"10.1016/j.jconrel.2015.10.030","title":"Programmable insect cell carriers for systemic delivery of integrated cancer biotherapy","year":2015,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Toronto General Hospital; Ontario Institute for Cancer Research; Children's Hospital of Eastern Ontario; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Ontario Institute for Cancer Research","keywords":"Systemic administration; Homing (biology); Oncolytic virus; Gene delivery; Cancer research; Cancer cell; Drosophila melanogaster; Biology; Cancer; Genetic enhancement; Cell; Transgene; Cell culture; In vivo; Computational biology; Gene; Biotechnology; Tumor cells; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571846,0.0002543351,0.0001954487,0.0001458686,0.000149457,0.0005040526,0.0002600724,0.0003069859,0.0009173038],"category_scores_gemma":[0.0001172632,0.0001355516,0.0001842729,0.0001496699,0.0002227738,0.0003028833,0.0002282922,0.0004838007,0.0004160744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003732019,"about_ca_system_score_gemma":0.0001627682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004651069,"about_ca_topic_score_gemma":0.0007229963,"domain_scores_codex":[0.9999068,0.00001139818,0.000006050122,0.00002030473,0.00003831018,0.00001718331],"domain_scores_gemma":[0.9999483,0.00001271628,0.00001702607,0.000008480894,0.000006522004,0.000006960377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003224513,0.000007272483,0.00003245962,0.000025009,0.000002592171,0.0000272828,0.00002207361,0.0001044607,0.9959062,0.0005405077,0.0000866906,0.00321298],"study_design_scores_gemma":[0.0000117678,0.0001063864,0.0002869867,0.000003698216,0.00001227226,0.0001055672,0.00001253484,0.001271901,0.9928559,0.00008133701,0.005245031,0.000006551523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8916463,0.004964496,0.09477737,0.0002103974,0.0001309545,0.0001843888,0.0007990127,0.0008392411,0.006447828],"genre_scores_gemma":[0.9584985,0.001877807,0.03177268,0.00006981302,0.00001570692,0.0001010589,0.0005106746,0.000112962,0.007040977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009173038,"threshold_uncertainty_score":0.003068745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199012378640553,"score_gpt":0.2976439169688614,"score_spread":0.2756537931824559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}