{"id":"W2149406788","doi":"10.1016/j.jconrel.2015.10.030","title":"Programmable insect cell carriers for systemic delivery of integrated cancer biotherapy","year":2015,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Toronto General Hospital; Ontario Institute for Cancer Research; Children's Hospital of Eastern Ontario; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Ontario Institute for Cancer Research","keywords":"Systemic administration; Homing (biology); Oncolytic virus; Gene delivery; Cancer research; Cancer cell; Drosophila melanogaster; Biology; Cancer; Genetic enhancement; Cell; Transgene; Cell culture; In vivo; Computational biology; Gene; Biotechnology; Tumor cells; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009493803,0.0001591779,0.000522209,0.0001439904,0.00003540912,0.00002144199,0.0002638964,0.0001488776,0.00001561632],"category_scores_gemma":[0.0001680396,0.0001144509,0.0003564234,0.0001369349,0.00007131166,0.000008523882,0.00001356971,0.0001522804,8.313586e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008824995,"about_ca_system_score_gemma":0.001851448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006816396,"about_ca_topic_score_gemma":0.0000437301,"domain_scores_codex":[0.9985286,0.0002143786,0.0005621081,0.0001474657,0.0002868834,0.0002605467],"domain_scores_gemma":[0.997493,0.00003986285,0.0005529209,0.0002095625,0.001452286,0.0002523531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.09231245,0.0001516269,0.000423049,0.0000610515,0.0005294027,0.0000137136,0.00007528134,0.001675215,0.8972736,0.000002106834,0.002864121,0.004618377],"study_design_scores_gemma":[0.05548798,0.01560282,0.0000074713,0.0001265363,0.0001702096,0.0000755869,0.0004620533,0.001430908,0.9069709,0.00003471402,0.01939152,0.0002392575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698164,0.02819242,0.0008111445,0.0001739092,0.0001794136,0.0007409946,0.00003142172,0.000004027701,0.00005019889],"genre_scores_gemma":[0.9962404,0.002392006,0.0002957729,0.0001411881,0.0002863329,0.00006280094,0.00001058805,0.00003354448,0.0005374035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03682446,"threshold_uncertainty_score":0.4667173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199012378640553,"score_gpt":0.2976439169688614,"score_spread":0.2756537931824559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}