{"id":"W2149451873","doi":"10.2337/db07-1129","title":"On the Pathogenicity of Autoantigen-Specific T-Cell Receptors","year":2008,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; American Lebanese Syrian Associated Charities; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Fondation pour la Recherche Médicale; Juvenile Diabetes Research Foundation International","keywords":"Insulitis; T-cell receptor; Adoptive cell transfer; Biology; T cell; Antigen; Islet; NOD mice; Immunology; Nod; Epitope; Molecular biology; Cell biology; Immune system; Endocrinology; Insulin; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132482,0.0001134955,0.0001202684,0.00002048762,0.0001028237,0.00000629327,0.0001910751,0.00008880225,0.00008563395],"category_scores_gemma":[0.00006114945,0.00008195966,0.0001313747,0.00009618827,0.0001161707,0.000001517866,0.00004425308,0.00006719028,0.00003201431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004787401,"about_ca_system_score_gemma":0.00002362996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002312365,"about_ca_topic_score_gemma":5.848013e-7,"domain_scores_codex":[0.9992611,0.00005633907,0.0001420993,0.0001928312,0.000118756,0.0002288375],"domain_scores_gemma":[0.9995111,0.00004484164,0.00008572437,0.0002753516,0.00004702734,0.00003600218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009795761,0.0002096445,0.04010917,0.000008119055,0.0000539943,4.826803e-7,0.00007329892,0.00003604348,0.9070306,0.0004266667,0.05065742,0.001384739],"study_design_scores_gemma":[0.0002756933,0.0002081111,0.006557387,0.000008888622,0.000006117255,1.011308e-7,0.00006184917,0.00001487933,0.9479956,0.0001943803,0.0445277,0.0001492989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993206,0.001345637,0.000007167234,0.0001153116,0.0001369773,0.00009853598,0.00002567888,0.00001036057,0.005054383],"genre_scores_gemma":[0.9983903,0.0005697747,0.00004426183,0.0003585391,0.00004843108,0.00001099014,0.00005221918,0.00001624491,0.0005092149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04096497,"threshold_uncertainty_score":0.3342218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008314187009201987,"score_gpt":0.186841106013522,"score_spread":0.1785269190043201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}