{"id":"W2149451873","doi":"10.2337/db07-1129","title":"On the Pathogenicity of Autoantigen-Specific T-Cell Receptors","year":2008,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; American Lebanese Syrian Associated Charities; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Fondation pour la Recherche Médicale; Juvenile Diabetes Research Foundation International","keywords":"Insulitis; T-cell receptor; Adoptive cell transfer; Biology; T cell; Antigen; Islet; NOD mice; Immunology; Nod; Epitope; Molecular biology; Cell biology; Immune system; Endocrinology; Insulin; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004555512,0.0003899059,0.0001304775,0.0002528305,0.0001224957,0.0003304708,0.0002408543,0.0004339861,0.001335599],"category_scores_gemma":[0.0004293372,0.0001019562,0.0001397474,0.00007677286,0.0003382105,0.000280424,0.0001952524,0.0004351985,0.0004555347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988099,"about_ca_system_score_gemma":0.0001380806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001945839,"about_ca_topic_score_gemma":0.0001731592,"domain_scores_codex":[0.9997094,0.00009426017,0.00001870707,0.00004351416,0.00006024784,0.00007373622],"domain_scores_gemma":[0.9995946,0.0002162312,0.0000506168,0.00003706907,0.0000501445,0.00005128423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001561645,0.0001872955,0.01461332,0.0002399524,0.00002619757,0.00130239,0.00009179787,0.000878119,0.9565354,0.001734335,0.0006326037,0.02219697],"study_design_scores_gemma":[0.0005854563,0.006935011,0.1108072,0.0003591011,0.0004337357,0.0158953,0.0004396871,0.0144387,0.82795,0.003690695,0.01842562,0.0000393334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880607,0.004745507,0.001732583,0.000371394,0.00006392442,0.00001766282,0.00006419739,0.00004333304,0.004900632],"genre_scores_gemma":[0.9961898,0.002184069,0.0004449868,0.0002134961,0.0001026341,0.00001502234,0.0001306884,0.000007862457,0.0007115098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335599,"threshold_uncertainty_score":0.004468024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008314187009201987,"score_gpt":0.186841106013522,"score_spread":0.1785269190043201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}