{"id":"W2149465719","doi":"10.1016/j.peptides.2011.01.020","title":"Antimicrobial decapeptide KSL-W attenuates Candida albicans virulence by modulating its effects on Toll-like receptor, human β-defensin, and cytokine expression by engineered human oral mucosa","year":2011,"lang":"en","type":"article","venue":"Peptides","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Candida albicans; Microbiology; Innate immune system; Defensin; Biology; Cytokine; Immune system; Antimicrobial; Receptor; Beta defensin; Corpus albicans; Antimicrobial peptides; Chemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214922,0.0002777713,0.0001689442,0.00009451559,0.00008136532,0.0002987017,0.0001301313,0.0001778618,0.0009057188],"category_scores_gemma":[0.0000967766,0.0001114176,0.0001417374,0.00007579446,0.000195565,0.0001496842,0.0001344433,0.0004749717,0.0002043917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001555476,"about_ca_system_score_gemma":0.0001901584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003005877,"about_ca_topic_score_gemma":0.0003798498,"domain_scores_codex":[0.9999,0.00001923959,0.00001114945,0.000013594,0.00001874758,0.0000371965],"domain_scores_gemma":[0.9999428,0.00001141902,0.00001634835,0.000007251453,0.000004986941,0.00001726352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004551681,0.00005400442,0.0001093157,0.00001567695,0.000002971881,0.00003650082,0.000009095637,0.00006241997,0.9982059,0.00003388046,0.00001205662,0.001003008],"study_design_scores_gemma":[0.0000368674,0.0005604135,0.001569793,0.000003265331,0.00001215092,0.0001086813,0.00002657681,0.0003957083,0.9968117,0.00001832622,0.0004541471,0.000002396214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999268,0.000246116,0.0002010808,0.00001748475,0.000006608874,0.000006054484,0.00003757088,0.000005986585,0.0002112527],"genre_scores_gemma":[0.9986155,0.0002078251,0.0003509833,0.00001885635,0.000004149761,0.000007049207,0.00007737069,0.00000427225,0.000714083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009057188,"threshold_uncertainty_score":0.003029943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486092150663092,"score_gpt":0.2264355897113631,"score_spread":0.2115746682047322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}