{"id":"W2149465719","doi":"10.1016/j.peptides.2011.01.020","title":"Antimicrobial decapeptide KSL-W attenuates Candida albicans virulence by modulating its effects on Toll-like receptor, human β-defensin, and cytokine expression by engineered human oral mucosa","year":2011,"lang":"en","type":"article","venue":"Peptides","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Candida albicans; Microbiology; Innate immune system; Defensin; Biology; Cytokine; Immune system; Antimicrobial; Receptor; Beta defensin; Corpus albicans; Antimicrobial peptides; Chemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002308402,0.0006461412,0.0007297246,0.0001570514,0.0009050783,0.00007888777,0.0003431247,0.000401233,0.0004494686],"category_scores_gemma":[0.00007223953,0.0005938345,0.0001557604,0.0001346585,0.0004081192,0.0003649271,0.0002257092,0.0005566411,0.0001662716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006994802,"about_ca_system_score_gemma":0.00002283819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258948,"about_ca_topic_score_gemma":0.0001160645,"domain_scores_codex":[0.9973996,0.0002435603,0.0005392669,0.0008479321,0.00009538375,0.0008741993],"domain_scores_gemma":[0.998904,0.0002063045,0.0002865351,0.0004053163,0.00009278664,0.0001050493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001350579,0.0001933425,0.001878562,0.00009018829,0.0001124892,0.00001038409,0.0007572363,0.000004074192,0.9176052,0.0001024974,0.0779474,0.001163632],"study_design_scores_gemma":[0.001559568,0.0004846901,0.001596693,0.0005415312,0.000067485,0.00003779331,0.0001694531,0.000006802455,0.9880546,0.00004494294,0.006713229,0.0007232593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968827,0.0007757162,0.0000781608,0.00008183695,0.0004572272,0.0004583141,0.0003852118,0.0002440841,0.0006367038],"genre_scores_gemma":[0.9947376,0.0001317107,0.0004807524,0.0005089673,0.00009783973,0.00003039607,0.0006311043,0.00009358314,0.003288053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07123417,"threshold_uncertainty_score":0.9996513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486092150663092,"score_gpt":0.2264355897113631,"score_spread":0.2115746682047322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}