{"id":"W2149510678","doi":"10.1124/jpet.112.200808","title":"The Heme Oxygenase System Selectively Enhances the Anti-Inflammatory Macrophage-M2 Phenotype, Reduces Pericardial Adiposity, and Ameliorated Cardiac Injury in Diabetic Cardiomyopathy in Zucker Diabetic Fatty Rats","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Research Council Canada","keywords":"Internal medicine; Endocrinology; Heme oxygenase; Macrophage polarization; Diabetic cardiomyopathy; Medicine; Inflammation; Cardiac function curve; Tumor necrosis factor alpha; M2 Macrophage; Protein kinase B; Insulin resistance; Insulin; Macrophage; Heme; Chemistry; Signal transduction; Cardiomyopathy; Heart failure; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003209913,0.0006224179,0.0005580609,0.0005051755,0.0002762105,0.0002975267,0.000308964,0.0004531989,0.001434912],"category_scores_gemma":[0.0001687504,0.0003038957,0.0002694936,0.0001746154,0.000545081,0.0003794531,0.0002715075,0.001222016,0.00023275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002759955,"about_ca_system_score_gemma":0.0003394333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007790958,"about_ca_topic_score_gemma":0.001301329,"domain_scores_codex":[0.9997948,0.00004382215,0.00001786849,0.00003470038,0.00003033435,0.00007844612],"domain_scores_gemma":[0.9997442,0.00001870241,0.00007125849,0.00002690549,0.00002041551,0.0001185566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003910352,0.0004887523,0.0002045399,0.00004971543,0.00001257932,0.00004480159,0.00002667399,0.00006464084,0.9930393,0.0001402751,0.00006168884,0.001956804],"study_design_scores_gemma":[0.0007962972,0.004830466,0.004589242,0.0000166921,0.0000983722,0.0001675002,0.00008849771,0.00104624,0.9869265,0.0001547332,0.001268628,0.00001674428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976414,0.0003768597,0.001330327,0.0001392133,0.00003780189,0.00002296241,0.00009120432,0.0000570322,0.0003031713],"genre_scores_gemma":[0.9954484,0.0004356556,0.001788343,0.00009004737,0.00003396351,0.00006521762,0.0001606991,0.00003384878,0.001943789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001434912,"threshold_uncertainty_score":0.00480032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00791754945729625,"score_gpt":0.271233569456504,"score_spread":0.2633160199992078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}