{"id":"W2149510678","doi":"10.1124/jpet.112.200808","title":"The Heme Oxygenase System Selectively Enhances the Anti-Inflammatory Macrophage-M2 Phenotype, Reduces Pericardial Adiposity, and Ameliorated Cardiac Injury in Diabetic Cardiomyopathy in Zucker Diabetic Fatty Rats","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Research Council Canada","keywords":"Internal medicine; Endocrinology; Heme oxygenase; Macrophage polarization; Diabetic cardiomyopathy; Medicine; Inflammation; Cardiac function curve; Tumor necrosis factor alpha; M2 Macrophage; Protein kinase B; Insulin resistance; Insulin; Macrophage; Heme; Chemistry; Signal transduction; Cardiomyopathy; Heart failure; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006722294,0.0002426616,0.000650615,0.000124807,0.0002578841,0.000074998,0.0001441384,0.0001235883,0.000009944363],"category_scores_gemma":[0.000006876558,0.0001507983,0.0002366072,0.0002683458,0.0004286068,0.0001702109,0.00009191834,0.0005487441,0.00000387351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000137594,"about_ca_system_score_gemma":0.0001393496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001941155,"about_ca_topic_score_gemma":5.501935e-7,"domain_scores_codex":[0.9978999,0.0007743303,0.0004779192,0.0002249855,0.000265113,0.0003577148],"domain_scores_gemma":[0.9992908,0.0001247264,0.0001952078,0.0001314052,0.0001050035,0.0001529048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007041097,0.0001738611,0.02285309,0.00004863637,0.001453911,0.0001173239,0.001178503,0.00002476601,0.9709989,0.000008926484,0.0001416468,0.002296292],"study_design_scores_gemma":[0.002292587,0.0003998852,0.1644703,0.00008277102,0.0008998586,0.0001299746,0.002266487,0.0003303822,0.828563,0.00001516717,0.0003474424,0.0002021259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.926273,0.0718915,0.000002946174,0.0004851473,0.0006302698,0.000652938,0.000005139266,0.00001133586,0.0000477118],"genre_scores_gemma":[0.9960963,0.002986929,0.00001644098,0.0004226734,0.0003815386,0.00006060052,0.000001432607,0.00002197037,0.00001218268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1424359,"threshold_uncertainty_score":0.6149377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00791754945729625,"score_gpt":0.271233569456504,"score_spread":0.2633160199992078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}