{"id":"W2149518639","doi":"10.1080/07391102.2000.10506641","title":"DNA Sequence Recognition of a Cross-Linked Polyamide: CD Studies, Footprinting and Effects on the Activity of DNA Gyrase","year":2000,"lang":"en","type":"article","venue":"Journal of Biomolecular Structure and Dynamics","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Brandenburger Staatsministerium für Wissenschaft, Forschung und Kultur","keywords":"Footprinting; Dimer; Chemistry; Netropsin; DNA; Stereochemistry; Linker; Circular dichroism; Monomer; Binding site; DNA gyrase; DNA footprinting; Base pair; Deoxyribonuclease I; Crystallography; Biochemistry; DNA-binding protein; Minor groove; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735236,0.0003915046,0.0002275446,0.0001227934,0.00007971443,0.000190352,0.0001795524,0.0003122992,0.001133917],"category_scores_gemma":[0.0002647523,0.0001425011,0.0001680684,0.0001366269,0.0002046663,0.00009786413,0.00008891094,0.0003987618,0.0002844762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001559373,"about_ca_system_score_gemma":0.0001026321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006722481,"about_ca_topic_score_gemma":0.0005360428,"domain_scores_codex":[0.99981,0.00005432265,0.00001184004,0.00004590263,0.00004798046,0.00002991905],"domain_scores_gemma":[0.9997084,0.00008948976,0.00006561525,0.00001962068,0.00004353612,0.00007334123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002280338,0.000009799243,0.00005039557,0.00001223304,0.000001899844,0.000008089633,0.000006927551,0.00002544799,0.9997109,0.000004816129,0.000003340562,0.0001433589],"study_design_scores_gemma":[0.00000300431,0.0001462121,0.001653807,0.000002608649,0.000003501367,0.00005867225,0.00001261487,0.0002247988,0.99767,0.000005893523,0.0002169659,0.000001931954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972603,0.0004700545,0.001552229,0.00003496675,0.00000882999,0.000009759835,0.0001010248,0.0000260733,0.0005368046],"genre_scores_gemma":[0.9974777,0.0001598342,0.001392081,0.000027935,0.000003876052,0.00001026537,0.000207253,0.00001057223,0.0007104384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133917,"threshold_uncertainty_score":0.003793359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093875889051492,"score_gpt":0.2744994765483493,"score_spread":0.2635607176578344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}