{"id":"W2149522649","doi":"10.2337/db13-1842","title":"Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen After Diabetes","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Heparanase; Internal medicine; Myocyte; Endocrinology; Lipoprotein lipase; Lipotoxicity; Downregulation and upregulation; Diabetes mellitus; Diabetic cardiomyopathy; Cell biology; Biology; Heparan sulfate; Chemistry; Medicine; Heparin; Insulin resistance; Adipose tissue; Biochemistry; Cardiomyopathy; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001677516,0.0002194063,0.000290043,0.0001427378,0.0001196306,0.0003921814,0.0001029999,0.0002256316,0.0008757818],"category_scores_gemma":[0.0001075256,0.000119935,0.0002771769,0.0001220679,0.0001903236,0.000256004,0.0002197352,0.0006115448,0.0002351991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002932143,"about_ca_system_score_gemma":0.0001698871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004823173,"about_ca_topic_score_gemma":0.0007000977,"domain_scores_codex":[0.9998499,0.00002758659,0.00001414018,0.00003033723,0.00002368446,0.00005419504],"domain_scores_gemma":[0.9998794,0.00001532151,0.00002465308,0.00001391927,0.00001764178,0.00004912787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002839418,0.00004899186,0.0004711795,0.00002193315,0.000005132826,0.00008412938,0.00002603889,0.00001772378,0.9981462,0.00005575768,0.00003006619,0.000809052],"study_design_scores_gemma":[0.00004639707,0.0007742353,0.03057728,0.00001334121,0.00004023777,0.0002111548,0.0001931732,0.0009249746,0.9658517,0.00008153741,0.001277675,0.000008384412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970461,0.001236198,0.0007653497,0.00007306735,0.00003128709,0.00001043938,0.00008438673,0.00001916205,0.0007340266],"genre_scores_gemma":[0.9956214,0.0009501448,0.0007782713,0.0000851056,0.00001704409,0.00001865468,0.0001674622,0.000009358969,0.00235253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008757818,"threshold_uncertainty_score":0.002929747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004484589907418376,"score_gpt":0.2067271095002444,"score_spread":0.2022425195928261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}