{"id":"W2149529721","doi":"10.1172/jci72241","title":"Prion disease tempo determined by host-dependent substrate reduction","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; Alberta Prion Research Institute; Centers for Disease Control and Prevention; U.S. Public Health Service; Canadian Institutes of Health Research; Alberta Innovates; Cleveland Clinic","keywords":"Downregulation and upregulation; Scrapie; Biology; Pathogenesis; Glycoprotein; Virology; Glycosylation; Chronic wasting disease; In vitro; Disease; Cell biology; Prion protein; Immunology; Molecular biology; Genetics; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002014979,0.0002273993,0.0002017794,0.0003030777,0.0001295426,0.0004446486,0.0001440571,0.0001957195,0.001779595],"category_scores_gemma":[0.0002096959,0.0001312663,0.00009976465,0.0001233225,0.0002055893,0.0002939479,0.000233929,0.0003672944,0.0005516202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620018,"about_ca_system_score_gemma":0.0001074153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002140589,"about_ca_topic_score_gemma":0.0002899703,"domain_scores_codex":[0.999851,0.00002140968,0.00001491979,0.00005084569,0.00003669073,0.0000251715],"domain_scores_gemma":[0.9998288,0.00002312178,0.00005006507,0.00002664185,0.00003078228,0.00004064024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001459582,0.00003190883,0.001260315,0.00001908337,0.000004101481,0.000082593,0.00001719787,0.00001389767,0.9963951,0.0001503762,0.00006823095,0.001811174],"study_design_scores_gemma":[0.00002042004,0.001254901,0.08452587,0.00001788093,0.00002803279,0.002227664,0.00007975965,0.001168961,0.9047267,0.0004158147,0.005518757,0.00001525771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989848,0.002865276,0.002488278,0.00007214872,0.0000449206,0.00005335827,0.0004148085,0.0001587863,0.004054482],"genre_scores_gemma":[0.9954975,0.0008922299,0.0008657898,0.0000451452,0.00001634645,0.00002801536,0.0003636951,0.00002075454,0.002270511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779595,"threshold_uncertainty_score":0.005953312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03350529041783667,"score_gpt":0.3366516527672306,"score_spread":0.3031463623493939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}