{"id":"W2149564446","doi":"10.1158/1535-7163.mct-06-0106","title":"Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma","year":2006,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Immunohistochemistry; Biology; Glioma; Methylation; DNA methylation; O-6-methylguanine-DNA methyltransferase; Molecular biology; Methyltransferase; DNA; Cancer research; Pathology; Immunology; Biochemistry; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005534175,0.0002943301,0.0002338221,0.0009548154,0.0001088748,0.0002310949,0.0001583291,0.0003055574,0.0006844117],"category_scores_gemma":[0.001102122,0.0001821674,0.00012859,0.0005234834,0.0002791364,0.000175756,0.0001511731,0.0002729557,0.00026873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372952,"about_ca_system_score_gemma":0.0001141428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005142473,"about_ca_topic_score_gemma":0.00068336,"domain_scores_codex":[0.9994205,0.0001613156,0.00003729699,0.00009661177,0.0002321053,0.00005214255],"domain_scores_gemma":[0.999572,0.0001472023,0.000113835,0.00003914372,0.0000932226,0.00003471919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004705694,0.00004430781,0.01402701,0.0001023257,0.0000256718,0.00006267182,0.00009844179,0.0001558978,0.9758439,0.00005201408,0.00004044144,0.009076718],"study_design_scores_gemma":[0.00002946482,0.001271292,0.2218678,0.00001743204,0.00007360226,0.001198233,0.000117825,0.004461946,0.7687784,0.0001282819,0.002036979,0.0000186744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884362,0.001878489,0.008244945,0.00002859028,0.00001302288,0.00006663346,0.0003487933,0.000119085,0.0008641628],"genre_scores_gemma":[0.9851677,0.0006950248,0.01221031,0.00002547353,0.00001203397,0.0001823445,0.0007004857,0.00002010835,0.0009866216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009548154,"threshold_uncertainty_score":0.002926767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899061330498693,"score_gpt":0.3014807369575591,"score_spread":0.2824901236525722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}