{"id":"W2149573012","doi":"10.1038/bcj.2014.51","title":"High DNA-methyltransferase 3B expression predicts poor outcome in acute myeloid leukemia, especially among patients with co-occurring NPM1 and FLT3 mutations","year":2014,"lang":"en","type":"letter","venue":"Blood Cancer Journal","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"NPM1; DNMT3B; CEBPA; Methyltransferase; Oncology; Myeloid leukemia; Hazard ratio; Internal medicine; Medicine; Hematology; Transplantation; Biology; Immunology; Cancer research; Genetics; Confidence interval; Mutation; Methylation; Karyotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006521956,0.0008342982,0.001465237,0.001124557,0.0004051316,0.0002821585,0.0005407634,0.001025631,0.0004671883],"category_scores_gemma":[0.0001709486,0.0006461892,0.0002306826,0.0004431681,0.0003837998,0.0004799669,0.0001141625,0.007613698,0.00001394517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00179801,"about_ca_system_score_gemma":0.002348466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005792145,"about_ca_topic_score_gemma":0.0001502276,"domain_scores_codex":[0.9940172,0.0004062199,0.001288057,0.0009165208,0.002098086,0.001273956],"domain_scores_gemma":[0.9972911,0.0003195723,0.0005972519,0.0005622391,0.0005527999,0.0006770177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001296688,0.0003017374,0.737052,0.0008295319,0.001804848,0.008252209,0.0009826926,0.0001394631,0.001743011,0.000002000234,0.2444547,0.00314113],"study_design_scores_gemma":[0.09885628,0.004733606,0.7339662,0.01359823,0.008241933,0.003099541,0.0002415271,0.0002169866,0.01475337,0.0001205498,0.1187414,0.003430336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615147,0.000457301,0.0002980853,0.03476483,0.0005887813,0.001464258,0.0005477278,0.00007863357,0.0002857238],"genre_scores_gemma":[0.6546993,0.003222971,0.006211876,0.3013341,0.02605481,0.0009606747,0.002572641,0.001091979,0.003851613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3068154,"threshold_uncertainty_score":0.9995989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438939337097395,"score_gpt":0.2827906529000513,"score_spread":0.2684012595290774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}