{"id":"W2149579582","doi":"10.1016/j.cell.2014.10.044","title":"Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institutes of Health; National Institute of General Medical Sciences; Canadian Institute for Advanced Research","keywords":"Biology; Cryptococcus neoformans; Antifungal drug; Genetics; Pathogen; Genetic screen; Virulence; Gene; Genome; Human pathogen; Computational biology; Phenotype; Candida albicans","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004108161,0.0002802647,0.0002612127,0.0005331198,0.0004947503,0.001271457,0.0005714619,0.0008416633,0.001173575],"category_scores_gemma":[0.0002828082,0.0001612891,0.0002283999,0.0002163241,0.001309056,0.001088047,0.0007852003,0.001509366,0.000283545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005582716,"about_ca_system_score_gemma":0.0007682366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007512241,"about_ca_topic_score_gemma":0.0009259074,"domain_scores_codex":[0.9998148,0.00003990768,0.000009633659,0.00002088895,0.0000828647,0.000031883],"domain_scores_gemma":[0.9998443,0.0000472634,0.00003352385,0.00001800815,0.00002364567,0.00003333368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008150417,0.0000464605,0.001188638,0.00009929652,0.000008329694,0.0003598877,0.0001199908,0.0004372154,0.9581712,0.02032556,0.0005076755,0.01865416],"study_design_scores_gemma":[0.00003741738,0.0005549978,0.006172131,0.00008884173,0.00005463598,0.003245956,0.001103477,0.00534009,0.8637956,0.02147325,0.09809122,0.0000424026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8092684,0.03512527,0.09718054,0.02175677,0.001020792,0.000158428,0.0005269515,0.0004464686,0.03451649],"genre_scores_gemma":[0.9330276,0.02147305,0.0366501,0.001710043,0.0002324287,0.00004681558,0.0001685216,0.00005250608,0.006638811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001271457,"threshold_uncertainty_score":0.004050553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276688001848017,"score_gpt":0.2770017863100701,"score_spread":0.2493329861252684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}