{"id":"W2149579582","doi":"10.1016/j.cell.2014.10.044","title":"Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institutes of Health; National Institute of General Medical Sciences; Canadian Institute for Advanced Research","keywords":"Biology; Cryptococcus neoformans; Antifungal drug; Genetics; Pathogen; Genetic screen; Virulence; Gene; Genome; Human pathogen; Computational biology; Phenotype; Candida albicans","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151175,0.00004998732,0.0001236314,0.00001896176,0.00004987775,0.000002347592,0.00002920502,0.00004126607,0.00002022238],"category_scores_gemma":[0.00004738943,0.00003199319,0.00004533636,0.0000577942,0.00007284045,0.00000375907,0.00003570402,0.00007192983,0.000004560151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001118925,"about_ca_system_score_gemma":0.00001504207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002063104,"about_ca_topic_score_gemma":8.966086e-7,"domain_scores_codex":[0.9996464,0.00002034402,0.0001097625,0.00007842461,0.00003796996,0.0001071558],"domain_scores_gemma":[0.9997105,0.00006638761,0.00003375956,0.0001138953,0.00005093183,0.00002454635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006104946,0.00002280824,0.01010618,0.00002341153,0.00001604936,8.905143e-7,0.0001745765,0.0000199422,0.9884594,0.0001095596,0.00006995593,0.0009910943],"study_design_scores_gemma":[0.0006502216,0.0002715229,0.002861482,0.00004236043,0.0001675799,0.00006013332,0.0002090302,0.01058169,0.9706675,0.0002791025,0.01410261,0.0001067349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912524,0.0009844545,0.001598393,0.0000777953,0.0001038731,0.00005908021,0.000003645056,0.000009428822,0.005910879],"genre_scores_gemma":[0.9977494,0.00005586148,0.001891562,0.000057237,0.0001608102,0.00000176158,0.000002591916,0.000006185524,0.0000746013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01779191,"threshold_uncertainty_score":0.1304644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276688001848017,"score_gpt":0.2770017863100701,"score_spread":0.2493329861252684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}