{"id":"W2149585871","doi":"10.1073/pnas.0706645104","title":"Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Hôpital Notre-Dame","funders":"Deutsche Morbus Crohn/Colitis Ulcerosa Vereinigung; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; European Commission; Crohn's and Colitis Foundation","keywords":"Biology; Genetics; Haplotype; Locus (genetics); Genome-wide association study; Genome; Allele; Founder effect; Gene; Population; Disease; Candidate gene; Genetic association; Single-nucleotide polymorphism; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006360727,0.0003654397,0.0002846514,0.000965342,0.001353791,0.0005642672,0.0003416769,0.0003408021,0.005420729],"category_scores_gemma":[0.001530978,0.0001075621,0.0002806848,0.001222261,0.0004298294,0.0001189546,0.0003918204,0.0005402646,0.0002681891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003569076,"about_ca_system_score_gemma":0.002536015,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.865541,"about_ca_topic_score_gemma":0.9112645,"domain_scores_codex":[0.9996572,0.00007837723,0.00001514126,0.0001151669,0.00006345837,0.00007062448],"domain_scores_gemma":[0.9993402,0.0001620416,0.0001037533,0.00006081859,0.0002174851,0.0001155732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004718784,0.0000610342,0.9498438,0.00006384463,0.0004887839,0.0008556108,0.0004569666,0.0005213303,0.01119561,0.0007269904,0.0031453,0.03216885],"study_design_scores_gemma":[0.00005925027,0.00005210564,0.9946885,0.00002921774,0.0001205917,0.0002870003,0.000156658,0.0006598632,0.0005136412,0.0001091807,0.003312763,0.00001128613],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870913,0.002169804,0.002266178,0.0007167474,0.00003352833,0.00006889757,0.003914947,0.00004691588,0.003691691],"genre_scores_gemma":[0.9961056,0.0004622517,0.001088863,0.0001134737,0.000009204718,0.00002295307,0.0008089137,0.000009333137,0.001379296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.134459,"threshold_uncertainty_score":0.2705016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02483676803751148,"score_gpt":0.3045876813948586,"score_spread":0.2797509133573471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}