{"id":"W2149623513","doi":"10.1128/aac.44.12.3317-3321.2000","title":"Interactions of Bacterial Cationic Peptide Antibiotics with Outer and Cytoplasmic Membranes of <i>Pseudomonas aeruginosa</i>","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":344,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Polymyxin; Pseudomonas aeruginosa; Polymyxin B; Gramicidin S; Gramicidin; Bacterial outer membrane; Depolarization; Cytoplasm; Peptide; Lipopolysaccharide; Microbiology; Biology; Biochemistry; Membrane; Bacteria; Chemistry; Antibiotics; Biophysics; Escherichia coli; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005331436,0.0002060497,0.0003884364,0.0000684845,0.0001235383,0.00002296446,0.00009805708,0.0001102303,0.001282785],"category_scores_gemma":[0.000002088285,0.0001672589,0.00006703546,0.00007634408,0.0005150608,0.000161774,0.00002551744,0.0001212335,0.00001176953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007247287,"about_ca_system_score_gemma":0.00003144308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000244329,"about_ca_topic_score_gemma":0.00006222964,"domain_scores_codex":[0.9991587,0.00003994116,0.0003071659,0.0002508937,0.00002867093,0.0002146719],"domain_scores_gemma":[0.9995561,0.00004276105,0.0001662451,0.0001622062,0.00005173223,0.00002100212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008016665,0.0002790932,0.008416064,0.0001420147,0.0003160437,0.000002694622,0.001159319,0.000009161069,0.9741155,0.00007696112,0.006794354,0.007887147],"study_design_scores_gemma":[0.002980801,0.0002640835,0.01193642,0.000212043,0.00009632898,0.0002761893,0.0001795996,0.000005949583,0.9345601,0.00002066668,0.04916856,0.0002992555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981759,0.00006631329,0.00002495651,0.0005194162,0.0001318187,0.0001741155,0.0001115913,0.00001933371,0.0007765834],"genre_scores_gemma":[0.9936336,0.002605151,0.000358436,0.0006361817,0.00003628019,5.869138e-7,0.00007960854,0.00002317689,0.002626923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04237421,"threshold_uncertainty_score":0.9996302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007555936655136642,"score_gpt":0.214991635100486,"score_spread":0.2074356984453493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}