{"id":"W2149623513","doi":"10.1128/aac.44.12.3317-3321.2000","title":"Interactions of Bacterial Cationic Peptide Antibiotics with Outer and Cytoplasmic Membranes of <i>Pseudomonas aeruginosa</i>","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":344,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Polymyxin; Pseudomonas aeruginosa; Polymyxin B; Gramicidin S; Gramicidin; Bacterial outer membrane; Depolarization; Cytoplasm; Peptide; Lipopolysaccharide; Microbiology; Biology; Biochemistry; Membrane; Bacteria; Chemistry; Antibiotics; Biophysics; Escherichia coli; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254682,0.0002198821,0.0001523824,0.0000671286,0.0001291861,0.0002388977,0.0001325609,0.0002508548,0.0006491421],"category_scores_gemma":[0.0002740854,0.00008702086,0.0001096009,0.00008693279,0.0001903347,0.0001952514,0.0001931179,0.0003442808,0.0002402444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446957,"about_ca_system_score_gemma":0.0001412311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003893363,"about_ca_topic_score_gemma":0.0003499358,"domain_scores_codex":[0.999822,0.00005538321,0.000007779401,0.00001718769,0.00004615386,0.00005157441],"domain_scores_gemma":[0.99985,0.00006239155,0.00003384938,0.000008433397,0.00002041204,0.0000248963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009498742,0.000009687938,0.000138943,0.0000267782,0.000002566603,0.00003410593,0.00001446859,0.00003113824,0.9986861,0.00005032529,0.00002137785,0.0008894817],"study_design_scores_gemma":[0.00001839309,0.000492989,0.006067463,0.0000152943,0.000008105128,0.0003371565,0.00009363257,0.0005505139,0.9907084,0.00005993216,0.001641509,0.000006624525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972542,0.0007590436,0.0005894343,0.00005459969,0.0000105777,0.00001060713,0.00005523334,0.000008217356,0.001258183],"genre_scores_gemma":[0.9977527,0.0005073887,0.0009646044,0.00006196764,0.000005465515,0.00001453372,0.0001559696,0.000005686874,0.000531654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006491421,"threshold_uncertainty_score":0.002171636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007555936655136642,"score_gpt":0.214991635100486,"score_spread":0.2074356984453493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}