{"id":"W2149645738","doi":"10.1002/cmdc.201590022","title":"Back Cover: Metabolic Instability of Cyanothiazolidine‐Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications (ChemMedChem 7/2015)","year":2015,"lang":"en","type":"paratext","venue":"ChemMedChem","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Oligopeptidase; Diastereomer; Chemistry; Cover (algebra); Stereochemistry; Computational biology; Biochemistry; Enzyme; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006464866,0.001207161,0.002517147,0.0003211333,0.00016198,0.00006965457,0.0004302856,0.001267769,0.01094854],"category_scores_gemma":[0.0003013323,0.001076382,0.0007779317,0.0007015083,0.001037618,0.0001954994,0.000330742,0.001353347,0.0006487879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005847962,"about_ca_system_score_gemma":0.001850554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007728644,"about_ca_topic_score_gemma":0.00000448294,"domain_scores_codex":[0.9942393,0.0001117448,0.001763594,0.001553008,0.001416336,0.0009159803],"domain_scores_gemma":[0.994644,0.0001101945,0.001214063,0.001588647,0.001117165,0.001325926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000890569,0.001655477,0.0002773799,0.007442339,0.001442054,0.0000369042,0.0006422768,0.00005641884,0.6760775,0.00003364909,0.3089465,0.002498976],"study_design_scores_gemma":[0.006430807,0.000216563,0.0002418938,0.001794582,0.001249152,0.0001564593,0.0002977983,0.0004586932,0.9503163,0.00007703734,0.03775762,0.001003073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7649103,0.01946658,0.0008716056,0.02346247,0.0007544089,0.005190834,0.005206502,0.0003252312,0.1798121],"genre_scores_gemma":[0.9728417,0.000558192,0.0007864088,0.0006630716,0.001834629,0.0003001967,0.005442289,0.0001716683,0.01740178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2742388,"threshold_uncertainty_score":0.9991686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686131402053324,"score_gpt":0.2996139773262236,"score_spread":0.2727526633056904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}