{"id":"W2149645738","doi":"10.1002/cmdc.201590022","title":"Back Cover: Metabolic Instability of Cyanothiazolidine‐Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications (ChemMedChem 7/2015)","year":2015,"lang":"en","type":"paratext","venue":"ChemMedChem","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Oligopeptidase; Diastereomer; Chemistry; Cover (algebra); Stereochemistry; Computational biology; Biochemistry; Enzyme; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003548067,0.0008533754,0.0006079137,0.0005710241,0.0006271657,0.001727418,0.0009852336,0.001197562,0.2287835],"category_scores_gemma":[0.0009293672,0.0003745497,0.0004612032,0.0005775245,0.0005150563,0.001534325,0.0008475556,0.001759192,0.06001583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001440246,"about_ca_system_score_gemma":0.0004626095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001494576,"about_ca_topic_score_gemma":0.002999002,"domain_scores_codex":[0.9997723,0.00001923869,0.000006385023,0.00002912228,0.0001362153,0.00003668319],"domain_scores_gemma":[0.9997427,0.00008960095,0.0000211178,0.00002390246,0.00005605973,0.00006673536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001871689,0.0000326183,0.00006414144,0.0002154268,0.00001072827,0.000080985,0.000007357482,0.001204463,0.002873679,0.003589841,0.956104,0.03562948],"study_design_scores_gemma":[0.0001855427,0.0002829042,0.001275797,0.0002167228,0.00002818774,0.0002432429,0.00003411287,0.01037068,0.01578334,0.0217911,0.9497457,0.00004274601],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.02040773,0.04332295,0.04438608,0.06485932,0.1087859,0.0004824907,0.03115909,0.01316621,0.6734303],"genre_scores_gemma":[0.09320875,0.0215001,0.01123072,0.01206394,0.01598641,0.0002514113,0.02212502,0.004101502,0.8195322],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.2287835,"threshold_uncertainty_score":0.7653571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686131402053324,"score_gpt":0.2996139773262236,"score_spread":0.2727526633056904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}