{"id":"W2149649252","doi":"10.1128/iai.00046-10","title":"<i>Leishmania donovani</i>Amastigotes Impair Gamma Interferon-Induced STAT1α Nuclear Translocation by Blocking the Interaction between STAT1α and Importin-α5","year":2010,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Canada Research Chairs","keywords":"Leishmania donovani; Biology; Amastigote; STAT1; Interferon gamma; STAT protein; Cell biology; Signal transduction; Nucleoplasm; Interferon regulatory factors; IRF1; Transcription factor; Immune system; Immunology; Leishmania; Visceral leishmaniasis; STAT3; Leishmaniasis; Innate immune system; Biochemistry; Cytoplasm; Nucleolus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006616468,0.0002169022,0.0002959557,0.0001326385,0.0006364245,0.0001498932,0.00008672631,0.0001343224,0.00007531555],"category_scores_gemma":[0.0003346454,0.0001651172,0.00007653055,0.0002340287,0.0002185163,0.0004102525,0.0001436861,0.001303043,0.000009141633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007641118,"about_ca_system_score_gemma":0.00004688985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002373547,"about_ca_topic_score_gemma":0.0005957058,"domain_scores_codex":[0.998625,0.0001932673,0.0003890251,0.0002707199,0.0002388217,0.000283143],"domain_scores_gemma":[0.9989544,0.0001758419,0.000182284,0.000349332,0.0001939793,0.0001441516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000195736,0.0001797112,0.269202,0.0001167805,0.0001829046,0.000001752108,0.00214811,5.495039e-7,0.6477988,0.00004897189,0.0009989773,0.07912578],"study_design_scores_gemma":[0.001673976,0.0008258558,0.9079138,0.0001569683,0.0001072672,0.0001169492,0.001064937,0.0002694488,0.07312537,0.00008733874,0.01440983,0.0002482584],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996747,0.00008679864,0.0001240238,0.001511166,0.0003484082,0.0005124639,0.00001209079,0.0001244977,0.0005335648],"genre_scores_gemma":[0.9990758,0.0004082334,0.00005280436,0.0001711234,0.0001361109,0.00001813655,0.00002009056,0.00003275007,0.00008494735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6387118,"threshold_uncertainty_score":0.6733283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02834842134376379,"score_gpt":0.3106508053778477,"score_spread":0.2823023840340839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}