{"id":"W2149649252","doi":"10.1128/iai.00046-10","title":"<i>Leishmania donovani</i>Amastigotes Impair Gamma Interferon-Induced STAT1α Nuclear Translocation by Blocking the Interaction between STAT1α and Importin-α5","year":2010,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Canada Research Chairs","keywords":"Leishmania donovani; Biology; Amastigote; STAT1; Interferon gamma; STAT protein; Cell biology; Signal transduction; Nucleoplasm; Interferon regulatory factors; IRF1; Transcription factor; Immune system; Immunology; Leishmania; Visceral leishmaniasis; STAT3; Leishmaniasis; Innate immune system; Biochemistry; Cytoplasm; Nucleolus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305981,0.0003703038,0.0002175,0.0001311147,0.0001293376,0.0002548657,0.0001859291,0.0002036787,0.001177151],"category_scores_gemma":[0.0000739985,0.0001414387,0.000241187,0.00008841565,0.0002670855,0.0001308845,0.0001427395,0.0005184129,0.0003856119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897639,"about_ca_system_score_gemma":0.0001674799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004722229,"about_ca_topic_score_gemma":0.0005807097,"domain_scores_codex":[0.9998498,0.00003469679,0.00001376053,0.00001889251,0.00002926881,0.00005352248],"domain_scores_gemma":[0.9999244,0.00001332743,0.00002822517,0.000008402859,0.00000842372,0.00001710763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002429821,0.00004567474,0.0001075915,0.00003619837,0.000003384254,0.00002364748,0.000009782376,0.00002819602,0.9989794,0.00008183758,0.00003125349,0.0004100956],"study_design_scores_gemma":[0.00003382284,0.0006423723,0.002558636,0.000008308634,0.00001007393,0.0002089836,0.0000290686,0.0004185681,0.9944719,0.00004286696,0.001573108,0.00000241742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962142,0.001088366,0.001013357,0.0001355381,0.00002421534,0.00002202369,0.0002339301,0.00006627999,0.001202075],"genre_scores_gemma":[0.9963605,0.0006137464,0.0009487985,0.00008057444,0.000009075688,0.00003053782,0.0005377383,0.00001683531,0.001402164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177151,"threshold_uncertainty_score":0.003938019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02834842134376379,"score_gpt":0.3106508053778477,"score_spread":0.2823023840340839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}