{"id":"W2149665909","doi":"10.1002/btpr.272","title":"Asymmetrically simultaneous synthesis of <scp>L</scp>‐homophenylalanine and <i>N</i><sup>6</sup>‐protected‐2‐oxo‐6‐amino‐hexanoic acid by engineered <i>Escherichia coli</i> aspartate aminotransferase","year":2009,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Public Health Agency of Canada","keywords":"Hexanoic acid; Escherichia coli; Chemistry; Lysine; Amino acid; Yield (engineering); Biochemistry; Enzyme; Stereochemistry; Enantioselective synthesis; Catalysis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002292622,0.000576959,0.0007322381,0.0002330543,0.0001292643,0.00003962106,0.0006037507,0.001253071,0.000005213599],"category_scores_gemma":[0.0008683582,0.0005501895,0.0001644699,0.0006625808,0.0005944534,0.00001379898,0.000147482,0.0004248245,0.000006895476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001820835,"about_ca_system_score_gemma":0.00006883189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207037,"about_ca_topic_score_gemma":0.000002423895,"domain_scores_codex":[0.9972849,0.0001065315,0.0006006961,0.0009065142,0.0002781012,0.0008232452],"domain_scores_gemma":[0.9984874,0.0001189306,0.0002179526,0.0007746809,0.0001636725,0.0002373527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009143448,0.0003592786,0.0002069405,0.0000771272,0.0001731119,0.00005038974,0.00005356516,0.00007013202,0.9448857,0.0002860175,0.001349706,0.0523966],"study_design_scores_gemma":[0.001091375,0.001140057,0.0004251672,0.00003768873,0.000143638,0.00007213736,0.00009747533,0.0009110433,0.9496636,0.00003281964,0.04607354,0.0003115009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770971,0.01803057,0.00285631,0.0005578626,0.00007831942,0.0007279115,0.0002195717,0.0002150564,0.0002173295],"genre_scores_gemma":[0.9903054,0.002170456,0.00639714,0.0003298954,0.0001153711,0.0001031461,0.0001182194,0.0000664257,0.0003939858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0520851,"threshold_uncertainty_score":0.9996949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003936898812369029,"score_gpt":0.199530038107197,"score_spread":0.195593139294828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}