{"id":"W2149690772","doi":"10.4049/jimmunol.174.12.7479","title":"Agonist Activity of the Small Molecule C3aR Ligand SB 290157","year":2005,"lang":"en","type":"letter","venue":"The Journal of Immunology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Agonist; Ligand (biochemistry); Chemistry; Molecule; Receptor; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001664968,0.0003951069,0.000853153,0.0002415801,0.0005709338,0.001124068,0.0009625203,0.001922419,0.008135722],"category_scores_gemma":[0.001441687,0.0002846072,0.0007665601,0.0001945475,0.00110421,0.0007162679,0.0006671097,0.005248209,0.002219599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003818965,"about_ca_system_score_gemma":0.0006316382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004498702,"about_ca_topic_score_gemma":0.00103003,"domain_scores_codex":[0.9994457,0.0002592411,0.00002998843,0.00006710497,0.0001087949,0.0000890517],"domain_scores_gemma":[0.9995179,0.0003115614,0.00004902822,0.00004056117,0.00004027159,0.00004067595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00909382,0.001031305,0.001446033,0.003633057,0.0003989461,0.002233807,0.001540775,0.001967699,0.6792121,0.07467756,0.0497457,0.1750192],"study_design_scores_gemma":[0.004350813,0.0297725,0.01168672,0.001484935,0.001020683,0.01418506,0.002209365,0.008868497,0.4297249,0.0321953,0.4641744,0.0003268459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5975315,0.09569911,0.02441511,0.09104639,0.01131804,0.0005635499,0.001156853,0.001277614,0.1769918],"genre_scores_gemma":[0.9127932,0.02598638,0.006238079,0.02728043,0.00172048,0.0002174311,0.0006157379,0.0001153894,0.02503285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008135722,"threshold_uncertainty_score":0.02721673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114766769029763,"score_gpt":0.2181055071464483,"score_spread":0.2069578394561507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}