{"id":"W2149700046","doi":"10.1089/ars.2015.6369","title":"Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms","year":2015,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Laurentian University; Thunder Bay Regional Research Institute","funders":"Canadian Institutes of Health Research; Lakehead University; Heart and Stroke Foundation of Canada","keywords":"Gluconeogenesis; Phosphoenolpyruvate carboxykinase; Internal medicine; Endocrinology; Chemistry; Cystathionine gamma-lyase; Protein kinase A; Cystathionine beta synthase; Biology; Biochemistry; Kinase; Enzyme; Metabolism; Cysteine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001053936,0.0001098534,0.0001598482,0.00003429367,0.00008611103,0.00002371222,0.0001617727,0.0000871993,0.000001753886],"category_scores_gemma":[0.0001701038,0.00006164066,0.00003544773,0.00008934655,0.0002914387,0.000004049899,0.0000797797,0.00006863394,3.769783e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003394378,"about_ca_system_score_gemma":0.00004409129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001623748,"about_ca_topic_score_gemma":0.00004045407,"domain_scores_codex":[0.9990808,0.0002198835,0.0002153978,0.0002176588,0.0001071354,0.0001591083],"domain_scores_gemma":[0.9994902,0.0001224896,0.00009748779,0.000202631,0.00004407643,0.00004312904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002414233,0.00002546674,0.001842227,0.0000120987,0.00003169278,0.00001231004,0.0004131243,0.00003156833,0.9940849,0.002074797,0.0000201153,0.001210308],"study_design_scores_gemma":[0.01485162,0.001241114,0.02096768,0.0003111244,0.0001623895,0.001277713,0.01620664,0.003429095,0.9029603,0.0355431,0.002077817,0.0009714324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923108,0.00369349,0.00338986,0.0002324493,0.0000651482,0.0001574322,0.000003579891,0.000003880381,0.0001433137],"genre_scores_gemma":[0.9979982,0.0005040125,0.001123823,0.0002870045,0.00003942108,0.000009195402,0.000008387795,0.000008488649,0.00002141042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09112458,"threshold_uncertainty_score":0.2513633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02891776008290907,"score_gpt":0.2730976489361931,"score_spread":0.244179888853284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}