{"id":"W2149700046","doi":"10.1089/ars.2015.6369","title":"Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms","year":2015,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Laurentian University; Thunder Bay Regional Research Institute","funders":"Canadian Institutes of Health Research; Lakehead University; Heart and Stroke Foundation of Canada","keywords":"Gluconeogenesis; Phosphoenolpyruvate carboxykinase; Internal medicine; Endocrinology; Chemistry; Cystathionine gamma-lyase; Protein kinase A; Cystathionine beta synthase; Biology; Biochemistry; Kinase; Enzyme; Metabolism; Cysteine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521544,0.0005122791,0.0003813155,0.0002274143,0.000102166,0.000272613,0.0002497025,0.000401491,0.001084463],"category_scores_gemma":[0.0001035255,0.0001483325,0.0002767847,0.000151116,0.0005207297,0.0002970123,0.0002354611,0.0004083064,0.0001951878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002804387,"about_ca_system_score_gemma":0.0002007605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000469006,"about_ca_topic_score_gemma":0.0006388504,"domain_scores_codex":[0.9998884,0.00001299147,0.00001690388,0.00003363745,0.00002652304,0.00002139532],"domain_scores_gemma":[0.9998679,0.0000098178,0.00005430839,0.00001668097,0.00001422367,0.00003706379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005279147,0.00002017909,0.0009450954,0.00008161182,0.00001344918,0.0001433571,0.000009706837,0.00003308308,0.9972379,0.00007692647,0.00002199361,0.0008886558],"study_design_scores_gemma":[0.00004243777,0.0004983289,0.02121211,0.00001374427,0.00006068157,0.0006275758,0.00007212316,0.0005312562,0.974781,0.0001423642,0.002010485,0.00000782404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912026,0.005213859,0.002349181,0.0002014784,0.00004298007,0.00002011919,0.0003364802,0.00008934397,0.000543949],"genre_scores_gemma":[0.9953445,0.00178771,0.0008972381,0.00006374784,0.00001605747,0.0000238756,0.0004500628,0.00001506191,0.001401757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001084463,"threshold_uncertainty_score":0.003627956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02891776008290907,"score_gpt":0.2730976489361931,"score_spread":0.244179888853284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}