{"id":"W2149731696","doi":"10.1016/s1474-4422(10)70254-4","title":"Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial","year":2010,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":680,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"UCB Pharma; U.S. Food and Drug Administration; Schering-Plough; National Institutes of Health; H. Lundbeck A/S; Teva Pharmaceutical Industries; Pfizer; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neurturin; Medicine; Clinical endpoint; Consolidated Standards of Reporting Trials; Adverse effect; Randomized controlled trial; Clinical trial; Internal medicine; Surgery; Neurotrophic factors; Glial cell line-derived neurotrophic factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004481842,0.003855219,0.01045849,0.001029871,0.0008326029,0.002251798,0.001782803,0.005530778,0.01043203],"category_scores_gemma":[0.004127863,0.001252713,0.00439924,0.001178394,0.002887739,0.002162286,0.0007057159,0.003918598,0.00164396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001305512,"about_ca_system_score_gemma":0.001578917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001975496,"about_ca_topic_score_gemma":0.00247809,"domain_scores_codex":[0.9974772,0.001281252,0.0002460299,0.0004584895,0.0002130865,0.0003238641],"domain_scores_gemma":[0.9982527,0.0007448483,0.0003783182,0.0001549944,0.0001427124,0.0003264605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9910159,0.0009520004,0.00006166068,0.001475448,0.001223084,0.00001871975,0.00002571895,0.00008633017,0.0009962341,0.00009475223,0.0003315888,0.00371849],"study_design_scores_gemma":[0.9885657,0.0102583,0.0001557901,0.00004796309,0.0004611242,0.000006001414,0.000007726226,0.0000892559,0.0000984135,0.00008752444,0.0002132788,0.000008941261],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8847528,0.05392091,0.007664103,0.003271079,0.009059995,0.02982276,0.004332038,0.000909676,0.006266603],"genre_scores_gemma":[0.9233022,0.01842237,0.006626087,0.00378986,0.002423071,0.03255874,0.001734972,0.0001333479,0.01100926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01045849,"threshold_uncertainty_score":0.03489864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03476311458167437,"score_gpt":0.3135376124543153,"score_spread":0.2787744978726409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}