{"id":"W2149757555","doi":"10.1091/mbc.e06-03-0218","title":"Opposite Effects of PSD-95 and MPP3 PDZ Proteins on Serotonin 5-Hydroxytryptamine<sub>2C</sub>Receptor Desensitization and Membrane Stability","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Centre National de la Recherche Scientifique","keywords":"Biology; PDZ domain; Desensitization (medicine); Receptor; Serotonin; Cell biology; 5-HT receptor; Membrane protein; Biophysics; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559177,0.0003144515,0.0003147169,0.0001514206,0.0001362008,0.0003603768,0.000203342,0.0003386319,0.0007375315],"category_scores_gemma":[0.000190334,0.0001726367,0.0003418672,0.000114929,0.0003350057,0.0002892472,0.000250177,0.0007256271,0.0001889561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003200537,"about_ca_system_score_gemma":0.0001366758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003844484,"about_ca_topic_score_gemma":0.0005687971,"domain_scores_codex":[0.9997717,0.00003313388,0.0000264488,0.00004713551,0.00005571671,0.00006594123],"domain_scores_gemma":[0.9998782,0.00002680592,0.00003430011,0.00001510471,0.000009610219,0.00003588904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002529392,0.00001969471,0.00009747567,0.00002337514,0.000007834022,0.00005218701,0.00001017955,0.00002143295,0.9989009,0.00008145221,0.00001393027,0.0005185338],"study_design_scores_gemma":[0.00005998201,0.0003732566,0.009772274,0.000003694417,0.00003269748,0.0004132062,0.00004532199,0.0006589991,0.9878128,0.00004940898,0.0007720279,0.000006345131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977163,0.0009420125,0.0006509286,0.00004366217,0.00002394756,0.00001176967,0.0001102246,0.00001798817,0.0004831546],"genre_scores_gemma":[0.9975522,0.0005376252,0.0007950092,0.00008328725,0.000008703604,0.00003375272,0.0001851516,0.000009412077,0.0007949402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007375315,"threshold_uncertainty_score":0.002467215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002648029146960051,"score_gpt":0.1832362709048454,"score_spread":0.1805882417578854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}