{"id":"W2149757555","doi":"10.1091/mbc.e06-03-0218","title":"Opposite Effects of PSD-95 and MPP3 PDZ Proteins on Serotonin 5-Hydroxytryptamine<sub>2C</sub>Receptor Desensitization and Membrane Stability","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Centre National de la Recherche Scientifique","keywords":"Biology; PDZ domain; Desensitization (medicine); Receptor; Serotonin; Cell biology; 5-HT receptor; Membrane protein; Biophysics; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002114391,0.0001972821,0.0002550819,0.00003361611,0.0000682332,0.000007666723,0.0001318047,0.0002610088,0.00000467795],"category_scores_gemma":[0.00006045336,0.0001534525,0.00009630295,0.00007962171,0.0002319665,0.000002892702,0.0001379577,0.00009579592,7.791427e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008827657,"about_ca_system_score_gemma":0.00002668722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004793898,"about_ca_topic_score_gemma":0.000008675984,"domain_scores_codex":[0.9988095,0.0002669788,0.0002521203,0.000379722,0.00009322014,0.0001984818],"domain_scores_gemma":[0.9993184,0.0000326982,0.0001864786,0.0003380673,0.00007673078,0.00004760702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007372229,0.00009305109,0.0009054663,0.0001808119,0.00002990596,0.000001031467,0.0000202614,0.00008053514,0.9979869,0.0002066047,0.00001739062,0.0004043039],"study_design_scores_gemma":[0.0006195469,0.0005754405,0.0005218929,0.00004320975,0.00003376167,0.00000436183,0.000008670121,0.0001971065,0.9973956,0.0003494217,0.00009860384,0.0001524013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934464,0.001302321,0.004281693,0.00007838359,0.00009898027,0.0006905992,0.00002160555,0.000007146876,0.00007290323],"genre_scores_gemma":[0.998589,0.0001628233,0.000993922,0.00008377451,0.00003649996,0.00002246466,0.00006828844,0.00002194596,0.00002125659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005142656,"threshold_uncertainty_score":0.6257612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002648029146960051,"score_gpt":0.1832362709048454,"score_spread":0.1805882417578854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}