{"id":"W2149758729","doi":"10.2741/lamothe","title":"Current develoments and future prospects for HIV gene therapy using interfering RNA-based strategies","year":2000,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Small interfering RNA; Biology; Viral replication; Virus; Gene; RNA; Virology; RNA interference; Genetic enhancement; Immune system; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002389339,0.0003243687,0.0007174392,0.0003531485,0.0002038935,0.00007575232,0.0003503385,0.0002089764,0.00002381066],"category_scores_gemma":[0.00001091002,0.0002318328,0.0001110402,0.000325043,0.0003313781,0.0001154636,0.00004924079,0.0002818938,0.00001372492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336929,"about_ca_system_score_gemma":0.0006858599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005827805,"about_ca_topic_score_gemma":0.000002336449,"domain_scores_codex":[0.998395,0.0001362609,0.0002989415,0.0005629481,0.00005578216,0.0005510871],"domain_scores_gemma":[0.9995739,0.00003840529,0.000115228,0.0002073496,0.00002428645,0.00004081507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004172787,0.00008705086,0.0001274396,0.0007785004,0.00005482377,0.000004575158,0.00007407522,8.572181e-7,0.00009403388,0.00001109467,0.0004536116,0.9982722],"study_design_scores_gemma":[0.0008495054,0.0001376109,0.0000386249,0.001786887,0.00003322699,0.0000122365,0.00006455878,0.00001767144,0.0003062696,0.00003872214,0.9964595,0.0002552018],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004826966,0.9938599,0.002720478,0.0000177,0.00138905,0.001255769,0.0002253981,0.0000207257,0.00002830662],"genre_scores_gemma":[0.0001589783,0.9945837,0.004728334,0.000008348921,0.0000536869,0.0001979423,0.0001866744,0.00001830348,0.00006407702],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.998017,"threshold_uncertainty_score":0.9453866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05059390821843942,"score_gpt":0.3439173504836771,"score_spread":0.2933234422652377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}