{"id":"W2149788223","doi":"10.1080/13816810802216480","title":"Successful<i>RPE65</i>Gene Replacement and Improved Visual Function in Humans","year":2008,"lang":"en","type":"editorial","venue":"Ophthalmic Genetics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre","funders":"","keywords":"RPE65; Function (biology); Biology; Medicine; Optometry; Ophthalmology; Genetics; Psychology; Gene; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002057644,0.0004547908,0.0003543874,0.0001299633,0.000111039,0.00005311736,0.0002432359,0.0009539393,0.00002769412],"category_scores_gemma":[0.0001137986,0.0004906568,0.00009211384,0.0001141227,0.000112956,0.000003651751,0.0002604839,0.0003466007,0.00001055506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004774411,"about_ca_system_score_gemma":0.0003668963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006443692,"about_ca_topic_score_gemma":0.0000894489,"domain_scores_codex":[0.9977355,0.00007546864,0.000489682,0.0008872706,0.0003764752,0.0004355924],"domain_scores_gemma":[0.9991041,0.00002815701,0.0002088575,0.0004015399,0.000144585,0.0001127578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001245002,0.0002797726,0.02332597,0.0002329825,0.0001915245,0.0000445272,0.0001181374,0.00004711563,0.1302478,0.000001440379,0.8423795,0.001886312],"study_design_scores_gemma":[0.002630537,0.002006015,0.006260402,0.00006419089,0.00007788335,0.00002590475,0.0001076554,0.00006783249,0.01338667,0.00004512999,0.9742371,0.001090619],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7840438,0.00633416,0.0001148334,0.00002195462,0.2072591,0.0005244479,0.00005280869,0.00001574999,0.001633088],"genre_scores_gemma":[0.5443836,0.04669736,0.001508043,0.0001563153,0.3853298,0.0002759181,0.00904949,0.0003203774,0.01227906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2396602,"threshold_uncertainty_score":0.9997545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005509456503326424,"score_gpt":0.2511377206031145,"score_spread":0.2456282640997881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}