{"id":"W2149790613","doi":"10.1139/y09-066","title":"Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatmentThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.","year":2009,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Grantová Agentura České Republiky","keywords":"Haloperidol; Sigma receptor; Guinea pig; Pharmacology; Desensitization (medicine); QT interval; Receptor; Internal medicine; Medicine; Chemistry; Dopamine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002166496,0.0004409615,0.0006020531,0.0001999441,0.0001281875,0.0002413692,0.000273639,0.0005318223,0.002550337],"category_scores_gemma":[0.0002298201,0.0002292228,0.0004111561,0.0001185619,0.0004349938,0.0002997349,0.0002036641,0.001484879,0.0004206618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206928,"about_ca_system_score_gemma":0.0002350668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005961219,"about_ca_topic_score_gemma":0.001257814,"domain_scores_codex":[0.9998246,0.00002512354,0.00001613416,0.00004936799,0.00003286755,0.00005191346],"domain_scores_gemma":[0.9996951,0.00008443215,0.00006341891,0.0000565407,0.00003149672,0.00006907035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002651877,0.00002639687,0.000106392,0.00003106875,0.000006234632,0.00008156888,0.00002850477,0.000007957633,0.9988084,0.00002073782,0.00002412066,0.0005935066],"study_design_scores_gemma":[0.00005219182,0.003514587,0.01969384,0.00001559125,0.00004588996,0.0004068783,0.0001121434,0.0002051697,0.9749601,0.00005109835,0.0009317268,0.00001075413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930708,0.003522353,0.001282786,0.0002122121,0.0001079931,0.00003236366,0.0004774232,0.00005897647,0.001235095],"genre_scores_gemma":[0.9909955,0.002676348,0.001690026,0.0002294345,0.00004581343,0.00009253438,0.0008892226,0.00003394411,0.0033472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002550337,"threshold_uncertainty_score":0.00853169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006850703268798245,"score_gpt":0.2597152493464877,"score_spread":0.2528645460776895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}